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MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness

miRNAs are essential factors of an extensively conserved post-transcriptional process controlling gene expression at mRNA level. Varoius biological processes such as growth and differentiation are regulated by miRNAs. Web of Science and PubMed databases were searched using the Endnote software for t...

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Autores principales: Mahmoodian sani, Mohammad Reza, Hashemzadeh-Chaleshtori, Morteza, Saidijam, Massoud, Jami, Mohammad-Saeid, Ghasemi-Dehkordi, Payam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Audiological Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144812/
https://www.ncbi.nlm.nih.gov/pubmed/27942598
http://dx.doi.org/10.7874/jao.2016.20.3.131
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author Mahmoodian sani, Mohammad Reza
Hashemzadeh-Chaleshtori, Morteza
Saidijam, Massoud
Jami, Mohammad-Saeid
Ghasemi-Dehkordi, Payam
author_facet Mahmoodian sani, Mohammad Reza
Hashemzadeh-Chaleshtori, Morteza
Saidijam, Massoud
Jami, Mohammad-Saeid
Ghasemi-Dehkordi, Payam
author_sort Mahmoodian sani, Mohammad Reza
collection PubMed
description miRNAs are essential factors of an extensively conserved post-transcriptional process controlling gene expression at mRNA level. Varoius biological processes such as growth and differentiation are regulated by miRNAs. Web of Science and PubMed databases were searched using the Endnote software for the publications about the role miRNA-183 family in inner ear: hair cell development and deafness published from 2000 to 2016. A triplet of these miRNAs particularly the miR-183 family is highly expressed in vertebrate hair cells, as with some of the peripheral neurosensory cells. Point mutations in one member of this family, miR-96, underlie DFNA50 autosomal deafness in humans and lead to abnormal hair cell development and survival in mice. In zebrafish, overexpression of the miR-183 family induces extra and ectopic hair cells, while knockdown decreases the number of hair cell. The miR-183 family (miR-183, miR-96 and miR-182) is expressed abundantly in some types of sensory cell in the eye, nose and inner ear. In the inner ear, mechanosensory hair cells have a robust expression level. Despite much similarity of these miRs sequences, small differences lead to distinct targeting of messenger RNAs targets. In the near future, miRNAs are likely to be explored as potential therapeutic agents to repair or regenerate hair cells, cell reprogramming and regenerative medicine applications in animal models because they can simultaneously down-regulate dozens or even hundreds of transcripts.
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spelling pubmed-51448122016-12-09 MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness Mahmoodian sani, Mohammad Reza Hashemzadeh-Chaleshtori, Morteza Saidijam, Massoud Jami, Mohammad-Saeid Ghasemi-Dehkordi, Payam J Audiol Otol Review miRNAs are essential factors of an extensively conserved post-transcriptional process controlling gene expression at mRNA level. Varoius biological processes such as growth and differentiation are regulated by miRNAs. Web of Science and PubMed databases were searched using the Endnote software for the publications about the role miRNA-183 family in inner ear: hair cell development and deafness published from 2000 to 2016. A triplet of these miRNAs particularly the miR-183 family is highly expressed in vertebrate hair cells, as with some of the peripheral neurosensory cells. Point mutations in one member of this family, miR-96, underlie DFNA50 autosomal deafness in humans and lead to abnormal hair cell development and survival in mice. In zebrafish, overexpression of the miR-183 family induces extra and ectopic hair cells, while knockdown decreases the number of hair cell. The miR-183 family (miR-183, miR-96 and miR-182) is expressed abundantly in some types of sensory cell in the eye, nose and inner ear. In the inner ear, mechanosensory hair cells have a robust expression level. Despite much similarity of these miRs sequences, small differences lead to distinct targeting of messenger RNAs targets. In the near future, miRNAs are likely to be explored as potential therapeutic agents to repair or regenerate hair cells, cell reprogramming and regenerative medicine applications in animal models because they can simultaneously down-regulate dozens or even hundreds of transcripts. The Korean Audiological Society 2016-12 2016-11-30 /pmc/articles/PMC5144812/ /pubmed/27942598 http://dx.doi.org/10.7874/jao.2016.20.3.131 Text en Copyright © 2016 The Korean Audiological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Mahmoodian sani, Mohammad Reza
Hashemzadeh-Chaleshtori, Morteza
Saidijam, Massoud
Jami, Mohammad-Saeid
Ghasemi-Dehkordi, Payam
MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
title MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
title_full MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
title_fullStr MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
title_full_unstemmed MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
title_short MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
title_sort microrna-183 family in inner ear: hair cell development and deafness
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144812/
https://www.ncbi.nlm.nih.gov/pubmed/27942598
http://dx.doi.org/10.7874/jao.2016.20.3.131
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