Cargando…

Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas

BACKGROUND: Despite therapeutic advances, survival with glioblastoma multiforme (GBM) remains below 15 months from diagnosis due to GBM’s highly infiltrative nature which precludes complete surgical resection. Patient outcomes could potentially be improved by targeting genes and pathways that drive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sturla, Lisa-Marie, Tong, Ming, Hebda, Nick, Gao, Jinsong, Thomas, John-Michael, Olsen, Mark, de la Monte, Suzanne M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144823/ https://www.ncbi.nlm.nih.gov/pubmed/27981247 http://dx.doi.org/10.1016/j.heliyon.2016.e00203

Ejemplares similares

Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target
por: Holtzman, Noa G., et al.
Publicado: (2021)

Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model
por: Tong, Ming, et al.
Publicado: (2017)

Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2014)

Hydroxylase Activity of ASPH Promotes Hepatocellular Carcinoma Metastasis Through Epithelial-to-Mesenchymal Transition Pathway
por: Zou, Qifei, et al.
Publicado: (2018)

Aspartate β-hydroxylase as a target for cancer therapy
por: Kanwal, Madiha, et al.
Publicado: (2020)

Correction: Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2019)

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility
por: Endo, Yukari, et al.
Publicado: (2022)

Diverse molecular functions of aspartate β-hydroxylase in cancer
por: Zheng, Wenqian, et al.
Publicado: (2020)

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer
por: Benelli, Roberto, et al.
Publicado: (2020)

ASPH Regulates Osteogenic Differentiation and Cellular Senescence of BMSCs
por: Peng, Hui, et al.
Publicado: (2020)

Role of aspartyl-(asparaginyl)-β-hydroxylase mediated notch signaling in cerebellar development and function
por: Silbermann, Elizabeth, et al.
Publicado: (2010)

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma
por: Tang, C, et al.
Publicado: (2017)

Study of Hemolysin Gene “aspHS” and Its Phenotype in Aspergillus Fumigatus
por: Zarrin, Majid, et al.
Publicado: (2019)

Overexpression of ASPH protein predicts poor outcomes in retroperitoneal liposarcoma patients
por: Xiao, Mengmeng, et al.
Publicado: (2023)

Characterization of the Relationship Between the Expression of Aspartate β-Hydroxylase and the Pathological Characteristics of Breast Cancer
por: Zhang, Yanan, et al.
Publicado: (2020)

Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer
por: Gan, Xuejun, et al.
Publicado: (2023)

Anti-Tumor Effects of Second Generation β-Hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression
por: Huang, Chiung-Kuei, et al.
Publicado: (2016)

Aspartyl-(asparaginyl) β-Hydroxylase, Hypoxia-Inducible Factor-1α and Notch Cross-Talk in Regulating Neuronal Motility
por: Lawton, Margot, et al.
Publicado: (2010)

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Novel Approach to Overcome Defects of Cell-SELEX in Developing Aptamers against Aspartate β-Hydroxylase
por: Bakhtiari, Hadi, et al.
Publicado: (2021)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Upregulation of circ-ASPH contributes to glioma cell proliferation and aggressiveness by targeting the miR-599/AR/SOCS2-AS1 signaling pathway
por: Qu, Yi, et al.
Publicado: (2021)

HMGA2 regulates circular RNA ASPH to promote tumor growth in lung adenocarcinoma
por: Xu, Li, et al.
Publicado: (2020)

CircASPH Promotes Hepatocellular Carcinoma Progression Through Methylation and Expression of HAO2
por: Zhuo, Han, et al.
Publicado: (2022)

Endocrine sensitivity of estrogen receptor‐positive breast cancer is negatively correlated with aspartate‐β‐hydroxylase expression
por: Shimoda, Masafumi, et al.
Publicado: (2017)

Construction and Characterization of Adenovirus Vectors Encoding Aspartate-β-Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma
por: Zhou, Yujiao, et al.
Publicado: (2018)

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway
por: Ogawa, Kosuke, et al.
Publicado: (2019)

INPP5F translocates into cytoplasm and interacts with ASPH to promote tumor growth in hepatocellular carcinoma
por: Zhou, Qianlei, et al.
Publicado: (2022)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971
por: Benelli, Roberto, et al.
Publicado: (2020)

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern
por: Pfeffer, Inga, et al.
Publicado: (2019)

Author Correction: Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis
por: Lin, Qiushi, et al.
Publicado: (2019)

Differential growth factor regulation of aspartyl-(asparaginyl)-β-hydroxylase family genes in SH-Sy5y human neuroblastoma cells
por: Lahousse, Stephanie A, et al.
Publicado: (2006)

Genetic diversity of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) genes in cattle breeds
por: Lourenco-Jaramillo, Diana Lelidett, et al.
Publicado: (2012)

Whole‐exome sequencing identified a novel homozygous ASPH frameshift variant causing Traboulsi syndrome in a Chinese family
por: Lei, Cheng, et al.
Publicado: (2020)

Circ_ASPH promotes cholangiocarcinoma growth and metastasis through the miR‐581/ATP‐binding cassette transporter G1 signaling pathway
por: Xu, Yi, et al.
Publicado: (2020)

CircASPH promotes KGN cells proliferation through miR‐375/MAP2K6 axis in Polycystic Ovary Syndrome
por: Wu, Gengxiang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_grr10j247va4ipm4sm71uvdf32