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Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013

We aimed to investigate transmission rates of pertussis in household contacts of cases and factors associated with transmission. A prospective epidemiological study was conducted in 2012 and 2013 to determine the incidence of pertussis among household contacts of reported cases in Catalonia and Nava...

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Autores principales: Godoy, Pere, García-Cenoz, Manuel, Toledo, Diana, Carmona, Glòria, Caylà, Joan A, Alsedà, Miquel, Àlvarez, Josep, Barrabeig, Irene, Camps, Neus, Plans, Pere, Castilla, Jesús, Sala-Farré, Maria-Rosa, Muñoz-Almagro, Carmen, Rius, Cristina, Domínguez, Àngela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144939/
https://www.ncbi.nlm.nih.gov/pubmed/27918260
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30393
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author Godoy, Pere
García-Cenoz, Manuel
Toledo, Diana
Carmona, Glòria
Caylà, Joan A
Alsedà, Miquel
Àlvarez, Josep
Barrabeig, Irene
Camps, Neus
Plans, Pere
Castilla, Jesús
Sala-Farré, Maria-Rosa
Muñoz-Almagro, Carmen
Rius, Cristina
Domínguez, Àngela
author_facet Godoy, Pere
García-Cenoz, Manuel
Toledo, Diana
Carmona, Glòria
Caylà, Joan A
Alsedà, Miquel
Àlvarez, Josep
Barrabeig, Irene
Camps, Neus
Plans, Pere
Castilla, Jesús
Sala-Farré, Maria-Rosa
Muñoz-Almagro, Carmen
Rius, Cristina
Domínguez, Àngela
author_sort Godoy, Pere
collection PubMed
description We aimed to investigate transmission rates of pertussis in household contacts of cases and factors associated with transmission. A prospective epidemiological study was conducted in 2012 and 2013 to determine the incidence of pertussis among household contacts of reported cases in Catalonia and Navarre, Spain. An epidemiological survey was completed for each case and contact, who were followed for 28 days to determine the source of infection (primary case) and detect the occurrence of secondary cases. Odds ratios (ORs) were used to estimate the effectiveness of vaccination and chemoprophylaxis in preventing new cases, using the formula (1 − OR) × 100. For the 688 primary cases, a total of 2,852 contacts were recorded. The household transmission rate was 16.1% (459/2,852) and rose according to the age (> 18 years) and lack of immunisation of the primary cases, and also the age (0–18 years), family relationship (siblings and children), lack of vaccination and chemoprophylaxis of contacts. Pertussis vaccine effectiveness in preventing new cases was 65.0% (95% confidence interval (CI): 11.6 to 86.2) for full vaccination (≥ 4 doses) and 59.7% (95% CI: −6.8 to 84.8) for incomplete vaccination (< 4 doses). The effectiveness of chemoprophylaxis was 62.1% (95% CI: 40.3 to 75.9). To reduce household transmission, contacts should be investigated to detect further cases and to administer chemoprophylaxis. The current vaccination status of cases and contacts can reduce household transmission.
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spelling pubmed-51449392016-12-12 Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013 Godoy, Pere García-Cenoz, Manuel Toledo, Diana Carmona, Glòria Caylà, Joan A Alsedà, Miquel Àlvarez, Josep Barrabeig, Irene Camps, Neus Plans, Pere Castilla, Jesús Sala-Farré, Maria-Rosa Muñoz-Almagro, Carmen Rius, Cristina Domínguez, Àngela Euro Surveill Research Article We aimed to investigate transmission rates of pertussis in household contacts of cases and factors associated with transmission. A prospective epidemiological study was conducted in 2012 and 2013 to determine the incidence of pertussis among household contacts of reported cases in Catalonia and Navarre, Spain. An epidemiological survey was completed for each case and contact, who were followed for 28 days to determine the source of infection (primary case) and detect the occurrence of secondary cases. Odds ratios (ORs) were used to estimate the effectiveness of vaccination and chemoprophylaxis in preventing new cases, using the formula (1 − OR) × 100. For the 688 primary cases, a total of 2,852 contacts were recorded. The household transmission rate was 16.1% (459/2,852) and rose according to the age (> 18 years) and lack of immunisation of the primary cases, and also the age (0–18 years), family relationship (siblings and children), lack of vaccination and chemoprophylaxis of contacts. Pertussis vaccine effectiveness in preventing new cases was 65.0% (95% confidence interval (CI): 11.6 to 86.2) for full vaccination (≥ 4 doses) and 59.7% (95% CI: −6.8 to 84.8) for incomplete vaccination (< 4 doses). The effectiveness of chemoprophylaxis was 62.1% (95% CI: 40.3 to 75.9). To reduce household transmission, contacts should be investigated to detect further cases and to administer chemoprophylaxis. The current vaccination status of cases and contacts can reduce household transmission. European Centre for Disease Prevention and Control (ECDC) 2016-11-10 /pmc/articles/PMC5144939/ /pubmed/27918260 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30393 Text en This article is copyright of ECDC, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Godoy, Pere
García-Cenoz, Manuel
Toledo, Diana
Carmona, Glòria
Caylà, Joan A
Alsedà, Miquel
Àlvarez, Josep
Barrabeig, Irene
Camps, Neus
Plans, Pere
Castilla, Jesús
Sala-Farré, Maria-Rosa
Muñoz-Almagro, Carmen
Rius, Cristina
Domínguez, Àngela
Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013
title Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013
title_full Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013
title_fullStr Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013
title_full_unstemmed Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013
title_short Factors influencing the spread of pertussis in households: a prospective study, Catalonia and Navarre, Spain, 2012 to 2013
title_sort factors influencing the spread of pertussis in households: a prospective study, catalonia and navarre, spain, 2012 to 2013
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144939/
https://www.ncbi.nlm.nih.gov/pubmed/27918260
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30393
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