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An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015

The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. Th...

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Autores principales: Lucidarme, Jay, Scott, Kevin J, Ure, Roisin, Smith, Andrew, Lindsay, Diane, Stenmark, Bianca, Jacobsson, Susanne, Fredlund, Hans, Cameron, J Claire, Smith-Palmer, Alison, McMenamin, Jim, Gray, Steve J, Campbell, Helen, Ladhani, Shamez, Findlow, Jamie, Mölling, Paula, Borrow, Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144941/
https://www.ncbi.nlm.nih.gov/pubmed/27918265
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30395
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author Lucidarme, Jay
Scott, Kevin J
Ure, Roisin
Smith, Andrew
Lindsay, Diane
Stenmark, Bianca
Jacobsson, Susanne
Fredlund, Hans
Cameron, J Claire
Smith-Palmer, Alison
McMenamin, Jim
Gray, Steve J
Campbell, Helen
Ladhani, Shamez
Findlow, Jamie
Mölling, Paula
Borrow, Ray
author_facet Lucidarme, Jay
Scott, Kevin J
Ure, Roisin
Smith, Andrew
Lindsay, Diane
Stenmark, Bianca
Jacobsson, Susanne
Fredlund, Hans
Cameron, J Claire
Smith-Palmer, Alison
McMenamin, Jim
Gray, Steve J
Campbell, Helen
Ladhani, Shamez
Findlow, Jamie
Mölling, Paula
Borrow, Ray
author_sort Lucidarme, Jay
collection PubMed
description The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. The isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged to the ST-11 clonal complex (cc11) which is associated with large outbreaks and high case fatality rates. Recent studies have demonstrated the need for high-resolution genomic typing schemes to assign serogroup W cc11 isolates to several distinct strains circulating globally over the past two decades. Here we used such schemes to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom. We also identify the genetic differences that define the novel strain including four point mutations and three putative recombination events involving the horizontal exchange of 17, six and two genes, respectively. Noteworthy outcomes of these changes were antigenic shifts and the disruption of a transcriptional regulator.
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spelling pubmed-51449412016-12-12 An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015 Lucidarme, Jay Scott, Kevin J Ure, Roisin Smith, Andrew Lindsay, Diane Stenmark, Bianca Jacobsson, Susanne Fredlund, Hans Cameron, J Claire Smith-Palmer, Alison McMenamin, Jim Gray, Steve J Campbell, Helen Ladhani, Shamez Findlow, Jamie Mölling, Paula Borrow, Ray Euro Surveill Research Article The 23rd World Scout Jamboree in 2015 took place in Japan and included over 33,000 scouts from 162 countries. Within nine days of the meeting ending, six cases of laboratory-confirmed invasive serogroup W meningococcal disease occurred among scouts and their close contacts in Scotland and Sweden. The isolates responsible were identical to one-another by routine typing and, where known (4 isolates), belonged to the ST-11 clonal complex (cc11) which is associated with large outbreaks and high case fatality rates. Recent studies have demonstrated the need for high-resolution genomic typing schemes to assign serogroup W cc11 isolates to several distinct strains circulating globally over the past two decades. Here we used such schemes to confirm that the Jamboree-associated cases constituted a genuine outbreak and that this was due to a novel and rapidly expanding strain descended from the strain that has recently expanded in South America and the United Kingdom. We also identify the genetic differences that define the novel strain including four point mutations and three putative recombination events involving the horizontal exchange of 17, six and two genes, respectively. Noteworthy outcomes of these changes were antigenic shifts and the disruption of a transcriptional regulator. European Centre for Disease Prevention and Control (ECDC) 2016-11-10 /pmc/articles/PMC5144941/ /pubmed/27918265 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30395 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Lucidarme, Jay
Scott, Kevin J
Ure, Roisin
Smith, Andrew
Lindsay, Diane
Stenmark, Bianca
Jacobsson, Susanne
Fredlund, Hans
Cameron, J Claire
Smith-Palmer, Alison
McMenamin, Jim
Gray, Steve J
Campbell, Helen
Ladhani, Shamez
Findlow, Jamie
Mölling, Paula
Borrow, Ray
An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
title An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
title_full An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
title_fullStr An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
title_full_unstemmed An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
title_short An international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup W strain, Scotland and Sweden, July to August 2015
title_sort international invasive meningococcal disease outbreak due to a novel and rapidly expanding serogroup w strain, scotland and sweden, july to august 2015
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144941/
https://www.ncbi.nlm.nih.gov/pubmed/27918265
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.45.30395
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