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Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016

Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained...

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Autores principales: Trudzinski, Franziska C., Schlotthauer, Uwe, Kamp, Annegret, Hennemann, Kai, Muellenbach, Ralf M., Reischl, Udo, Gärtner, Barbara, Wilkens, Heinrike, Bals, Robert, Herrmann, Mathias, Lepper, Philipp M., Becker, Sören L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144944/
https://www.ncbi.nlm.nih.gov/pubmed/27918254
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.46.30398
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author Trudzinski, Franziska C.
Schlotthauer, Uwe
Kamp, Annegret
Hennemann, Kai
Muellenbach, Ralf M.
Reischl, Udo
Gärtner, Barbara
Wilkens, Heinrike
Bals, Robert
Herrmann, Mathias
Lepper, Philipp M.
Becker, Sören L.
author_facet Trudzinski, Franziska C.
Schlotthauer, Uwe
Kamp, Annegret
Hennemann, Kai
Muellenbach, Ralf M.
Reischl, Udo
Gärtner, Barbara
Wilkens, Heinrike
Bals, Robert
Herrmann, Mathias
Lepper, Philipp M.
Becker, Sören L.
author_sort Trudzinski, Franziska C.
collection PubMed
description Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. chimaera might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of M. chimaera in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected M. chimaera in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and M. chimaera was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that M. chimaera can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of M. chimaera in ECMO treatment settings.
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spelling pubmed-51449442016-12-12 Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 Trudzinski, Franziska C. Schlotthauer, Uwe Kamp, Annegret Hennemann, Kai Muellenbach, Ralf M. Reischl, Udo Gärtner, Barbara Wilkens, Heinrike Bals, Robert Herrmann, Mathias Lepper, Philipp M. Becker, Sören L. Euro Surveill Research Article Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. chimaera might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of M. chimaera in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected M. chimaera in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and M. chimaera was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that M. chimaera can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of M. chimaera in ECMO treatment settings. European Centre for Disease Prevention and Control (ECDC) 2016-11-17 /pmc/articles/PMC5144944/ /pubmed/27918254 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.46.30398 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Trudzinski, Franziska C.
Schlotthauer, Uwe
Kamp, Annegret
Hennemann, Kai
Muellenbach, Ralf M.
Reischl, Udo
Gärtner, Barbara
Wilkens, Heinrike
Bals, Robert
Herrmann, Mathias
Lepper, Philipp M.
Becker, Sören L.
Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
title Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
title_full Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
title_fullStr Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
title_full_unstemmed Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
title_short Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
title_sort clinical implications of mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ecmo), germany, 2015 to 2016
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144944/
https://www.ncbi.nlm.nih.gov/pubmed/27918254
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.46.30398
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