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Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144944/ https://www.ncbi.nlm.nih.gov/pubmed/27918254 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.46.30398 |
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author | Trudzinski, Franziska C. Schlotthauer, Uwe Kamp, Annegret Hennemann, Kai Muellenbach, Ralf M. Reischl, Udo Gärtner, Barbara Wilkens, Heinrike Bals, Robert Herrmann, Mathias Lepper, Philipp M. Becker, Sören L. |
author_facet | Trudzinski, Franziska C. Schlotthauer, Uwe Kamp, Annegret Hennemann, Kai Muellenbach, Ralf M. Reischl, Udo Gärtner, Barbara Wilkens, Heinrike Bals, Robert Herrmann, Mathias Lepper, Philipp M. Becker, Sören L. |
author_sort | Trudzinski, Franziska C. |
collection | PubMed |
description | Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. chimaera might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of M. chimaera in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected M. chimaera in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and M. chimaera was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that M. chimaera can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of M. chimaera in ECMO treatment settings. |
format | Online Article Text |
id | pubmed-5144944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-51449442016-12-12 Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 Trudzinski, Franziska C. Schlotthauer, Uwe Kamp, Annegret Hennemann, Kai Muellenbach, Ralf M. Reischl, Udo Gärtner, Barbara Wilkens, Heinrike Bals, Robert Herrmann, Mathias Lepper, Philipp M. Becker, Sören L. Euro Surveill Research Article Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. chimaera might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of M. chimaera in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected M. chimaera in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and M. chimaera was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that M. chimaera can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of M. chimaera in ECMO treatment settings. European Centre for Disease Prevention and Control (ECDC) 2016-11-17 /pmc/articles/PMC5144944/ /pubmed/27918254 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.46.30398 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Research Article Trudzinski, Franziska C. Schlotthauer, Uwe Kamp, Annegret Hennemann, Kai Muellenbach, Ralf M. Reischl, Udo Gärtner, Barbara Wilkens, Heinrike Bals, Robert Herrmann, Mathias Lepper, Philipp M. Becker, Sören L. Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 |
title | Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 |
title_full | Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 |
title_fullStr | Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 |
title_full_unstemmed | Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 |
title_short | Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016 |
title_sort | clinical implications of mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ecmo), germany, 2015 to 2016 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144944/ https://www.ncbi.nlm.nih.gov/pubmed/27918254 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.46.30398 |
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