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Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania
BACKGROUND: The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS: A 6-month longitudinal study monitoring risk factors for anaemia and...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514496/ https://www.ncbi.nlm.nih.gov/pubmed/15282030 http://dx.doi.org/10.1186/1475-2875-3-26 |
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author | Lusingu, John PA Vestergaard, Lasse S Mmbando, Bruno P Drakeley, Chris J Jones, Caroline Akida, Juma Savaeli, Zacharia X Kitua, Andrew Y Lemnge, Martha M Theander, Thor G |
author_facet | Lusingu, John PA Vestergaard, Lasse S Mmbando, Bruno P Drakeley, Chris J Jones, Caroline Akida, Juma Savaeli, Zacharia X Kitua, Andrew Y Lemnge, Martha M Theander, Thor G |
author_sort | Lusingu, John PA |
collection | PubMed |
description | BACKGROUND: The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS: A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria episodes was conducted among individuals aged below 20 years, residing in three villages of different altitude in areas of high, moderate and low malaria transmission intensity in North-Eastern Tanzania. RESULTS: The burden of anaemia and malarial fever fell mainly on the youngest children and was highest in the village with high transmission intensity. Although a considerable percentage of individuals in all villages carried intestinal worms, logistic regression models indicated that Plasmodium falciparum was the only significant parasitic determinant of anaemia. Interestingly, children who carried low-density parasitaemia at the start of the study had a lower risk of contracting a febrile malaria episode but a higher risk of anaemia during the study period, than children who were slide negative at this point in time. CONCLUSION: Young children living in the high transmission village carried a very high anaemia burden, which could be attributed to malaria. The overall incidence of febrile malaria was also highest in the high transmission village particularly among those under five years of age. These data suggest that in rolling back malaria, available resources in prevention programmes should primarily be focussed on young children, particularly those residing in areas of high malaria transmission. |
format | Text |
id | pubmed-514496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-5144962004-08-22 Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania Lusingu, John PA Vestergaard, Lasse S Mmbando, Bruno P Drakeley, Chris J Jones, Caroline Akida, Juma Savaeli, Zacharia X Kitua, Andrew Y Lemnge, Martha M Theander, Thor G Malar J Research BACKGROUND: The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS: A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria episodes was conducted among individuals aged below 20 years, residing in three villages of different altitude in areas of high, moderate and low malaria transmission intensity in North-Eastern Tanzania. RESULTS: The burden of anaemia and malarial fever fell mainly on the youngest children and was highest in the village with high transmission intensity. Although a considerable percentage of individuals in all villages carried intestinal worms, logistic regression models indicated that Plasmodium falciparum was the only significant parasitic determinant of anaemia. Interestingly, children who carried low-density parasitaemia at the start of the study had a lower risk of contracting a febrile malaria episode but a higher risk of anaemia during the study period, than children who were slide negative at this point in time. CONCLUSION: Young children living in the high transmission village carried a very high anaemia burden, which could be attributed to malaria. The overall incidence of febrile malaria was also highest in the high transmission village particularly among those under five years of age. These data suggest that in rolling back malaria, available resources in prevention programmes should primarily be focussed on young children, particularly those residing in areas of high malaria transmission. BioMed Central 2004-07-28 /pmc/articles/PMC514496/ /pubmed/15282030 http://dx.doi.org/10.1186/1475-2875-3-26 Text en Copyright © 2004 Lusingu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Lusingu, John PA Vestergaard, Lasse S Mmbando, Bruno P Drakeley, Chris J Jones, Caroline Akida, Juma Savaeli, Zacharia X Kitua, Andrew Y Lemnge, Martha M Theander, Thor G Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania |
title | Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania |
title_full | Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania |
title_fullStr | Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania |
title_full_unstemmed | Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania |
title_short | Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania |
title_sort | malaria morbidity and immunity among residents of villages with different plasmodium falciparum transmission intensity in north-eastern tanzania |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514496/ https://www.ncbi.nlm.nih.gov/pubmed/15282030 http://dx.doi.org/10.1186/1475-2875-3-26 |
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