Cargando…

Coordinated Activation of VEGF/VEGFR-2 and PPARδ Pathways by a Multi-Component Chinese Medicine DHI Accelerated Recovery from Peripheral Arterial Disease in Type 2 Diabetic Mice

Diabetic mellitus (DM) patients are at an increased risk of developing peripheral arterial disease (PAD). Danhong injection (DHI) is a Chinese patent medicine widely used for several cardiovascular indications but the mechanism of action is not well-understood. We investigated the therapeutic potent...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Shuang, Zhao, Tiechan, Guo, Hao, Meng, Yanzhi, Qin, Gangjian, Goukassian, David A., Han, Jihong, Gao, Xuimei, Zhu, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145164/ https://www.ncbi.nlm.nih.gov/pubmed/27930695 http://dx.doi.org/10.1371/journal.pone.0167305

Ejemplares similares

A Defined Combination of Four Active Principles From the Danhong Injection Is Necessary and Sufficient to Accelerate EPC-Mediated Vascular Repair and Local Angiogenesis
por: He, Shuang, et al.
Publicado: (2019)

Mining of two novel aldehyde dehydrogenases (DHY-SC-VUT5 and DHY-G-VUT7) from metagenome of hydrocarbon contaminated soils
por: Baburam, Cindy, et al.
Publicado: (2021)

Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
por: Wang, Min, et al.
Publicado: (2019)

Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer
por: Dziobek, Konrad, et al.
Publicado: (2019)

Validity and Reliability of the Persian Version of the Dysphagia Handicap Index (DHI)
por: Asadollahpour, Faezeh, et al.
Publicado: (2015)

Diagnostic Value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline Mammary Carcinoma
por: Nascimento, Catarina, et al.
Publicado: (2021)

Genetic variations in VEGF and VEGFR2 and glioblastoma outcome
por: Sjöström, S., et al.
Publicado: (2010)

VEGF-dependent tumor angiogenesis requires the inverse and reciprocal regulation of VEGFR1 and VEGFR2
por: Zhang, Zhaocheng, et al.
Publicado: (2009)

Microtubules Coordinate VEGFR2 Signaling and Sorting
por: Czeisler, Catherine, et al.
Publicado: (2013)

Effects of oestradiol and tamoxifen on VEGF, soluble VEGFR-1, and VEGFR-2 in breast cancer and endothelial cells
por: Garvin, S, et al.
Publicado: (2005)

VEGF-VEGFR Signals in Health and Disease
por: Shibuya, Masabumi
Publicado: (2014)

Effects of Melatonin on Dairy Herd Improvement (DHI) of Holstein Cow with High SCS
por: Wu, Hao, et al.
Publicado: (2021)

Association between intratumoral free and total VEGF, soluble VEGFR-1, VEGFR-2 and prognosis in breast cancer
por: Bando, H, et al.
Publicado: (2005)

Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models
por: Dev, I K, et al.
Publicado: (2004)

Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies
por: Meng, Qian, et al.
Publicado: (2016)

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2
por: Peach, Chloe J., et al.
Publicado: (2018)

Targeting VEGF/VEGFR to Modulate Antitumor Immunity
por: Yang, Ju, et al.
Publicado: (2018)

Seasonal expressions of VEGF and its receptors VEGFR1 and VEGFR2 in the prostate of the wild ground squirrels (Spermophilus dauricus)
por: Yao, Yuchen, et al.
Publicado: (2021)

Cross-Cultural Adaptation and Validation of the Italian Version of the Dysphagia Handicap Index (I-DHI)
por: Ginocchio, Daniela, et al.
Publicado: (2021)

NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?
por: Mackenzie, Gerardo G., et al.
Publicado: (2008)

DSGOST inhibits tumor growth by blocking VEGF/VEGFR2-activated angiogenesis
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2
por: Choi, Hyeong Sim, et al.
Publicado: (2016)

Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation
por: Huang, Xionggao, et al.
Publicado: (2017)

Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity
por: Hu, Zhengping, et al.
Publicado: (2020)

VEGF/VEGFR2 signaling regulates hippocampal axon branching during development
por: Luck, Robert, et al.
Publicado: (2019)

Inhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment
por: Luo, Ya-Li, et al.
Publicado: (2023)

PPAR-δ in Vascular Pathophysiology
por: Wang, Nanping
Publicado: (2008)

Counterbalance: modulation of VEGF/VEGFR activities by TNFSF15
por: Yang, Gui-Li, et al.
Publicado: (2018)

The VEGF/VEGFR Axis Revisited: Implications for Cancer Therapy
por: Mabeta, Peace, et al.
Publicado: (2022)

Structure-Based Design of Peptides Targeting VEGF/VEGFRs
por: Di Stasi, Rossella, et al.
Publicado: (2023)

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3
por: Xu, Yunling, et al.
Publicado: (2010)

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
por: Fearnley, Gareth W., et al.
Publicado: (2016)

ScFvs as Allosteric Inhibitors of VEGFR-2: Novel Tools to Harness VEGF Signaling
por: Ballmer-Hofer, Kurt, et al.
Publicado: (2018)

Prognostic value and association of Lauren classification with VEGF and VEGFR-2 expression in gastric cancer
por: Li, Xiayi, et al.
Publicado: (2019)

Role of NDEL1 and VEGF/VEGFR-2 in Mouse Hippocampus After Status Epilepticus
por: Zhu, Lin, et al.
Publicado: (2020)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo
por: Higgins, Larry G., et al.
Publicado: (2012)

Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies
por: Hao, Jia, et al.
Publicado: (2015)

Validity of Italian adaptation of the Dizziness Handicap Inventory (DHI) and evaluation of the quality of life in patients with acute dizziness
por: NOLA, G., et al.
Publicado: (2010)

Fingerprint-based deep neural networks can model thermodynamic and optical properties of eumelanin DHI dimers
por: Bosch, Daniel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qdjaat8nnn86i1e2am2s63r7tk