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Avertin®, but Not Volatile Anesthetics Addressing the Two-Pore Domain K+ Channel, TASK-1, Slows Down Cilia-Driven Particle Transport in the Mouse Trachea
RATIONALE: Volatile anesthetics inhibit mucociliary clearance in the airways. The two-pore domain K(+) channel, TASK-1, represents one of their molecular targets in that they increase its open probability. Here, we determine whether particle transport speed (PTS) at the mucosal surface of the mouse...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145217/ https://www.ncbi.nlm.nih.gov/pubmed/27930725 http://dx.doi.org/10.1371/journal.pone.0167919 |