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A dual function fusion protein of Herpes simplex virus type 1 thymidine kinase and firefly luciferase for noninvasive in vivo imaging of gene therapy in malignant glioma

BACKGROUND: Suicide gene therapy employing the prodrug activating system Herpes simplex virus type 1 thymidine kinase (HSV-TK)/ ganciclovir (GCV) has proven to be effective in killing experimental brain tumors. In contrast, glioma patients treated with HSV-TK/ GCV did not show significant treatment...

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Detalles Bibliográficos
Autores principales:	Söling, Ariane, Theiß, Christian, Jungmichel, Stephanie, Rainov, Nikolai G
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514571/ https://www.ncbi.nlm.nih.gov/pubmed/15294018 http://dx.doi.org/10.1186/1479-0556-2-7

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