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Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome

CONTEXT: Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. OBJECTIVE: To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing’s syndrome (CS) and to evaluate the occurrence...

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Autores principales: Abalem, Maria Fernanda, Machado, Marcio Carlos, Santos, Helen Nazareth Veloso Dos, Garcia, Rafael, Helal, John, Carricondo, Pedro Carlos, Pimentel, Sérgio Luis Gianotti, Monteiro, Mario Luiz Ribeiro, Qian, Cynthia X., Bronstein, Marcello Delano, Fragoso, Maria Cândida Villares Barisson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145875/
https://www.ncbi.nlm.nih.gov/pubmed/28018289
http://dx.doi.org/10.3389/fendo.2016.00154
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author Abalem, Maria Fernanda
Machado, Marcio Carlos
Santos, Helen Nazareth Veloso Dos
Garcia, Rafael
Helal, John
Carricondo, Pedro Carlos
Pimentel, Sérgio Luis Gianotti
Monteiro, Mario Luiz Ribeiro
Qian, Cynthia X.
Bronstein, Marcello Delano
Fragoso, Maria Cândida Villares Barisson
author_facet Abalem, Maria Fernanda
Machado, Marcio Carlos
Santos, Helen Nazareth Veloso Dos
Garcia, Rafael
Helal, John
Carricondo, Pedro Carlos
Pimentel, Sérgio Luis Gianotti
Monteiro, Mario Luiz Ribeiro
Qian, Cynthia X.
Bronstein, Marcello Delano
Fragoso, Maria Cândida Villares Barisson
author_sort Abalem, Maria Fernanda
collection PubMed
description CONTEXT: Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. OBJECTIVE: To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing’s syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients. DESIGN: Cross-sectional study. SETTING: Outpatient clinic. PATIENTS: Eleven female patients with CS in hypercortisolism state as determined by the presence of at least two abnormal measurements from urinary cortisol 24 h, no suppression of cortisol with low dose dexamethasone suppression test, and nocturnal salivary cortisol levels and 12 healthy controls. METHODS: Choroidal and retinal morphology was assessed using OCT. MAIN OUTCOME MEASURES: Choroidal thickness measurements and the presence of retinal changes. RESULTS: The mean subfoveal choroidal thickness was 372.96 ± 73.14 µm in the patients with CS and 255.63 ± 50.70 µm in the control group (p < 0.001). One patient (9.09%) presented with central serous chorioretinopathy and one patient (9.09%) with pachychoroid pigment epitheliopathy. CONCLUSION: Choroidal thickness is increased in the eyes of patients with active CS compared to healthy and matched control. Also, 18.18% of patients presented with macular changes, possibly secondary to choroidal thickening. While further studies are necessary to confirm our findings, excess corticosteroid levels seem to have a significant effect on the choroid and might be associated with secondary retinal diseases.
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spelling pubmed-51458752016-12-23 Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome Abalem, Maria Fernanda Machado, Marcio Carlos Santos, Helen Nazareth Veloso Dos Garcia, Rafael Helal, John Carricondo, Pedro Carlos Pimentel, Sérgio Luis Gianotti Monteiro, Mario Luiz Ribeiro Qian, Cynthia X. Bronstein, Marcello Delano Fragoso, Maria Cândida Villares Barisson Front Endocrinol (Lausanne) Endocrinology CONTEXT: Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. OBJECTIVE: To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing’s syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients. DESIGN: Cross-sectional study. SETTING: Outpatient clinic. PATIENTS: Eleven female patients with CS in hypercortisolism state as determined by the presence of at least two abnormal measurements from urinary cortisol 24 h, no suppression of cortisol with low dose dexamethasone suppression test, and nocturnal salivary cortisol levels and 12 healthy controls. METHODS: Choroidal and retinal morphology was assessed using OCT. MAIN OUTCOME MEASURES: Choroidal thickness measurements and the presence of retinal changes. RESULTS: The mean subfoveal choroidal thickness was 372.96 ± 73.14 µm in the patients with CS and 255.63 ± 50.70 µm in the control group (p < 0.001). One patient (9.09%) presented with central serous chorioretinopathy and one patient (9.09%) with pachychoroid pigment epitheliopathy. CONCLUSION: Choroidal thickness is increased in the eyes of patients with active CS compared to healthy and matched control. Also, 18.18% of patients presented with macular changes, possibly secondary to choroidal thickening. While further studies are necessary to confirm our findings, excess corticosteroid levels seem to have a significant effect on the choroid and might be associated with secondary retinal diseases. Frontiers Media S.A. 2016-12-09 /pmc/articles/PMC5145875/ /pubmed/28018289 http://dx.doi.org/10.3389/fendo.2016.00154 Text en Copyright © 2016 Abalem, Machado, Santos, Garcia, Helal, Carricondo, Pimentel, Monteiro, Qian, Bronstein and Fragoso. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Abalem, Maria Fernanda
Machado, Marcio Carlos
Santos, Helen Nazareth Veloso Dos
Garcia, Rafael
Helal, John
Carricondo, Pedro Carlos
Pimentel, Sérgio Luis Gianotti
Monteiro, Mario Luiz Ribeiro
Qian, Cynthia X.
Bronstein, Marcello Delano
Fragoso, Maria Cândida Villares Barisson
Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
title Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
title_full Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
title_fullStr Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
title_full_unstemmed Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
title_short Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing’s Syndrome
title_sort choroidal and retinal abnormalities by optical coherence tomography in endogenous cushing’s syndrome
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145875/
https://www.ncbi.nlm.nih.gov/pubmed/28018289
http://dx.doi.org/10.3389/fendo.2016.00154
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