Cargando…
Epidemiological evidence of higher susceptibility to vCJD in the young
BACKGROUND: The strikingly young age of new variant Creutzfeldt-Jacob disease (vCJD) cases remains unexplained. Age dependent susceptibility to infection has been put forward, but differential dietary exposure to contaminated food products in the UK population according to age and sex during the bov...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2004
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514608/ https://www.ncbi.nlm.nih.gov/pubmed/15304199 http://dx.doi.org/10.1186/1471-2334-4-26 |
_version_ | 1782121733737676800 |
---|---|
author | Boëlle, Pierre-Yves Cesbron, Jean-Yves Valleron, Alain-Jacques |
author_facet | Boëlle, Pierre-Yves Cesbron, Jean-Yves Valleron, Alain-Jacques |
author_sort | Boëlle, Pierre-Yves |
collection | PubMed |
description | BACKGROUND: The strikingly young age of new variant Creutzfeldt-Jacob disease (vCJD) cases remains unexplained. Age dependent susceptibility to infection has been put forward, but differential dietary exposure to contaminated food products in the UK population according to age and sex during the bovine spongiform encephalopathy (BSE) epidemic may provide a simpler explanation. METHODS: Using recently published estimates of dietary exposure in mathematical models of the epidemiology of the new variant Creutzfeldt Jacob disease (vCJD), we examine whether the age characteristics of vCJD cases may be reproduced. RESULTS: The susceptibility/exposure risk function has likely peaked in adolescents and was followed by a sharp decrease with age, evocative of the profile of exposure to bovine material consumption according to age. However, assuming that the risk of contamination was proportional to exposure, with no age dependent susceptibility, the model failed to reproduce the observed age characteristics of the vCJD cases: The predicted cumulated proportion of cases over 40 years was 48%, in strong disagreement with the observed 10%. Incorporating age dependent susceptibility led to a cumulated proportion of cases over 40 years old of 12%. CONCLUSIONS: This analysis provides evidence that differential dietary exposure alone fails to explain the pattern of age in vCJD cases. Decreasing age related susceptibility is required to reproduce the characteristics of the age distribution of vCJD cases. |
format | Text |
id | pubmed-514608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-5146082004-08-28 Epidemiological evidence of higher susceptibility to vCJD in the young Boëlle, Pierre-Yves Cesbron, Jean-Yves Valleron, Alain-Jacques BMC Infect Dis Research Article BACKGROUND: The strikingly young age of new variant Creutzfeldt-Jacob disease (vCJD) cases remains unexplained. Age dependent susceptibility to infection has been put forward, but differential dietary exposure to contaminated food products in the UK population according to age and sex during the bovine spongiform encephalopathy (BSE) epidemic may provide a simpler explanation. METHODS: Using recently published estimates of dietary exposure in mathematical models of the epidemiology of the new variant Creutzfeldt Jacob disease (vCJD), we examine whether the age characteristics of vCJD cases may be reproduced. RESULTS: The susceptibility/exposure risk function has likely peaked in adolescents and was followed by a sharp decrease with age, evocative of the profile of exposure to bovine material consumption according to age. However, assuming that the risk of contamination was proportional to exposure, with no age dependent susceptibility, the model failed to reproduce the observed age characteristics of the vCJD cases: The predicted cumulated proportion of cases over 40 years was 48%, in strong disagreement with the observed 10%. Incorporating age dependent susceptibility led to a cumulated proportion of cases over 40 years old of 12%. CONCLUSIONS: This analysis provides evidence that differential dietary exposure alone fails to explain the pattern of age in vCJD cases. Decreasing age related susceptibility is required to reproduce the characteristics of the age distribution of vCJD cases. BioMed Central 2004-08-10 /pmc/articles/PMC514608/ /pubmed/15304199 http://dx.doi.org/10.1186/1471-2334-4-26 Text en Copyright © 2004 Boëlle et al; licensee BioMed Central Ltd. |
spellingShingle | Research Article Boëlle, Pierre-Yves Cesbron, Jean-Yves Valleron, Alain-Jacques Epidemiological evidence of higher susceptibility to vCJD in the young |
title | Epidemiological evidence of higher susceptibility to vCJD in the young |
title_full | Epidemiological evidence of higher susceptibility to vCJD in the young |
title_fullStr | Epidemiological evidence of higher susceptibility to vCJD in the young |
title_full_unstemmed | Epidemiological evidence of higher susceptibility to vCJD in the young |
title_short | Epidemiological evidence of higher susceptibility to vCJD in the young |
title_sort | epidemiological evidence of higher susceptibility to vcjd in the young |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514608/ https://www.ncbi.nlm.nih.gov/pubmed/15304199 http://dx.doi.org/10.1186/1471-2334-4-26 |
work_keys_str_mv | AT boellepierreyves epidemiologicalevidenceofhighersusceptibilitytovcjdintheyoung AT cesbronjeanyves epidemiologicalevidenceofhighersusceptibilitytovcjdintheyoung AT valleronalainjacques epidemiologicalevidenceofhighersusceptibilitytovcjdintheyoung |