Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders

The recent identification of multiple new genetic causes of neurological disorders highlights the need for model systems that give experimental access to the underlying biology. In particular, the ability to couple disease-causing mutations with human neuronal differentiation systems would be benefi...

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Detalles Bibliográficos
Autores principales: Shah, Ruth R., Cholewa-Waclaw, Justyna, Davies, Faith C.J., Paton, Katie M., Chaligne, Ronan, Heard, Edith, Abbott, Catherine M., Bird, Adrian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Method Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146642/
https://www.ncbi.nlm.nih.gov/pubmed/27976757
http://dx.doi.org/10.12688/wellcomeopenres.10011.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146642/
https://www.ncbi.nlm.nih.gov/pubmed/27976757
http://dx.doi.org/10.12688/wellcomeopenres.10011.1

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