Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model

Drug-induced cholestasis is a leading cause of drug withdrawal. However, the use of primary human hepatocytes (PHHs), the gold standard for predicting cholestasis in vitro, is limited by their high cost and batch-to-batch variability. Mature hepatocyte characteristics have been observed in human ind...

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Detalles Bibliográficos
Autores principales: Ni, Xuan, Gao, Yimeng, Wu, Zhitao, Ma, Leilei, Chen, Chen, Wang, Le, Lin, Yunfei, Hui, Lijian, Pan, Guoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146671/
https://www.ncbi.nlm.nih.gov/pubmed/27934920
http://dx.doi.org/10.1038/srep38694

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