MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

BACKGROUND: Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell survival and chemo-resistance in a wide range of malignancies, and thus its inhibition may prove to be therapeutically useful. M...

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Detalles Bibliográficos
Autores principales: Young, Adelaide I. J., Law, Andrew M. K., Castillo, Lesley, Chong, Sabrina, Cullen, Hayley D., Koehler, Martin, Herzog, Sebastian, Brummer, Tilman, Lee, Erinna F., Fairlie, Walter D., Lucas, Morghan C., Herrmann, David, Allam, Amr, Timpson, Paul, Watkins, D. Neil, Millar, Ewan K. A., O’Toole, Sandra A., Gallego-Ortega, David, Ormandy, Christopher J., Oakes, Samantha R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146841/
https://www.ncbi.nlm.nih.gov/pubmed/27931239
http://dx.doi.org/10.1186/s13058-016-0781-6

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