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Autophagy induced by a sulphamoylated estrone analogue contributes to its cytotoxic effect on breast cancer cells

BACKGROUND: Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in silico-designed 17-β-estradiol analogue that induces both autophagy and apoptosis...

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Detalles Bibliográficos
Autores principales:	Verwey, Marcel, Nolte, Elsie M., Joubert, Anna M., Theron, Anne E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146855/ https://www.ncbi.nlm.nih.gov/pubmed/27980456 http://dx.doi.org/10.1186/s12935-016-0367-5

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