Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

BACKGROUND: Apolipoprotein E (apoE) is a major carrier of cholesterol and essential for synaptic plasticity. In brain, it’s expressed by many cells but highly expressed by the choroid plexus and the predominant apolipoprotein in cerebrospinal fluid (CSF). The role of apoE in the CSF is unclear. Rece...

Descripción completa

Detalles Bibliográficos
Autores principales: Achariyar, Thiyagaragan M., Li, Baoman, Peng, Weiguo, Verghese, Philip B., Shi, Yang, McConnell, Evan, Benraiss, Abdellatif, Kasper, Tristan, Song, Wei, Takana, Takahiro, Holtzman, David M., Nedergaard, Maiken, Deane, Rashid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146863/
https://www.ncbi.nlm.nih.gov/pubmed/27931262
http://dx.doi.org/10.1186/s13024-016-0138-8

Ejemplares similares

Ejemplares similares