Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing

BACKGROUND: Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in t...

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Detalles Bibliográficos
Autores principales: Demeulemeester, Jonas, Kumar, Parveen, Møller, Elen K., Nord, Silje, Wedge, David C., Peterson, April, Mathiesen, Randi R., Fjelldal, Renathe, Zamani Esteki, Masoud, Theunis, Koen, Fernandez Gallardo, Elia, Grundstad, A. Jason, Borgen, Elin, Baumbusch, Lars O., Børresen-Dale, Anne-Lise, White, Kevin P., Kristensen, Vessela N., Van Loo, Peter, Voet, Thierry, Naume, Bjørn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146893/
https://www.ncbi.nlm.nih.gov/pubmed/27931250
http://dx.doi.org/10.1186/s13059-016-1109-7

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