Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity

Inducing α-helicity through side-chain cross-linking is a strategy that has been pursued to improve peptide conformational rigidity and bio-availability. Here we describe the preparation of small peptides tethered to chiral sulfoxide-containing macrocyclic rings. Furthermore, a study of structure-ac...

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Detalles Bibliográficos
Autores principales: Zhang, Qingzhou, Jiang, Fan, Zhao, Bingchuan, Lin, Huacan, Tian, Yuan, Xie, Mingsheng, Bai, Guoyun, Gilbert, Adam M., Goetz, Gilles H., Liras, Spiros, Mathiowetz, Alan A., Price, David A., Song, Kun, Tu, Meihua, Wu, Yujie, Wang, Tao, Flanagan, Mark E., Wu, Yun-Dong, Li, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146914/
https://www.ncbi.nlm.nih.gov/pubmed/27934919
http://dx.doi.org/10.1038/srep38573

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