Cargando…

AR-12 Inhibits Chaperone Proteins Preventing Virus Replication and the Accumulation of Toxic Misfolded Proteins

Detalles Bibliográficos
Autores principales:	Booth, Laurence, Roberts, Jane L, Ecroyd, Heath, Reid, St. Patrick, Proniuk, Stefan, Zukiwski, Alexander, Jacob, Abraham, Damonte, Elsa, Tuñón, María J, Dent, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146995/ https://www.ncbi.nlm.nih.gov/pubmed/27957385 http://dx.doi.org/10.4172/2155-9899.1000454

Ejemplares similares

Multi-kinase inhibitors can associate with heat shock proteins through their NH(2)-termini by which they suppress chaperone function
por: Booth, Laurence, et al.
Publicado: (2016)

The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions
por: Abdulrahman, Basant A., et al.
Publicado: (2017)

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
por: Mannini, Benedetta, et al.
Publicado: (2017)

Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells
por: San Gil, Rebecca, et al.
Publicado: (2017)

Chaperoning Proteins for Destruction: Diverse Roles of Hsp70 Chaperones and their Co-Chaperones in Targeting Misfolded Proteins to the Proteasome
por: Shiber, Ayala, et al.
Publicado: (2014)

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes
por: Zhang, Xingqian, et al.
Publicado: (2011)

Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones
por: Rousseau, Erwann, et al.
Publicado: (2009)

Emerging novel concept of chaperone therapies for protein misfolding diseases
por: SUZUKI, Yoshiyuki
Publicado: (2014)

Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
por: Abildgaard, Amanda B., et al.
Publicado: (2020)

How soluble misfolded proteins bypass chaperones at the molecular level
por: Halder, Ritaban, et al.
Publicado: (2023)

Real-time single-molecule observation of chaperone-assisted protein folding
por: Marzano, Nicholas R., et al.
Publicado: (2022)

Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration
por: Ali, Yousuf O., et al.
Publicado: (2010)

Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins
por: Mattoo, Rayees U. H., et al.
Publicado: (2014)

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity
por: Brehme, Marc, et al.
Publicado: (2016)

Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones
por: Underhaug, Jarl, et al.
Publicado: (2012)

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function
por: Mateju, Daniel, et al.
Publicado: (2017)

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease
por: Rutledge, Benjamin S., et al.
Publicado: (2022)

Proteins with RNA Chaperone Activity: A World of Diverse Proteins with a Common Task—Impediment of RNA Misfolding
por: Semrad, Katharina
Publicado: (2011)

Diminished Self-Chaperoning Activity of the ΔF508 Mutant of CFTR Results in Protein Misfolding
por: Serohijos, Adrian W. R., et al.
Publicado: (2008)

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness to stress
por: Escusa-Toret, Stéphanie, et al.
Publicado: (2013)

The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
por: Jung, Jinsei, et al.
Publicado: (2016)

A prion-like domain in Hsp42 drives chaperone-facilitated aggregation of misfolded proteins
por: Grousl, Tomas, et al.
Publicado: (2018)

Extensive accumulation of misfolded protein aggregates during natural aging and senescence
por: Cuanalo-Contreras, Karina, et al.
Publicado: (2023)

Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates
por: Kaku, Hiroaki, et al.
Publicado: (2022)

Role of Protein Misfolding and Proteostasis Deficiency in Protein Misfolding Diseases and Aging
por: Cuanalo-Contreras, Karina, et al.
Publicado: (2013)

AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication
por: Rayner, Jonathan O., et al.
Publicado: (2020)

Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity
por: Chhangani, Deepak, et al.
Publicado: (2013)

Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly
por: Hervás, Rubén, et al.
Publicado: (2020)

Prion Protein Misfolding
por: Kupfer, L, et al.
Publicado: (2009)

Protein misfolding diseases
por: Ventura, Salvador
Publicado: (2015)

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases
por: Morales, Rodrigo, et al.
Publicado: (2013)

PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide
por: Booth, Laurence, et al.
Publicado: (2016)

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases
por: Cristofani, Riccardo, et al.
Publicado: (2017)

Class-specific interactions between Sis1 J-domain protein and Hsp70 chaperone potentiate disaggregation of misfolded proteins
por: Wyszkowski, Hubert, et al.
Publicado: (2021)

Yeast derlin Dfm1 employs a chaperone-like function to resolve misfolded membrane protein stress
por: Kandel, Rachel, et al.
Publicado: (2023)

In Vivo Generation of Neurotoxic Prion Protein: Role for Hsp70 in Accumulation of Misfolded Isoforms
por: Fernandez-Funez, Pedro, et al.
Publicado: (2009)

Stress induced nuclear granules form in response to accumulation of misfolded proteins in Caenorhabditis elegans
por: Sampuda, Katherine M., et al.
Publicado: (2017)

Protein Folding and Misfolding on Surfaces
por: Stefani, Massimo
Publicado: (2008)

Protein misfolding disorders and macroautophagy
por: Menzies, Fiona M, et al.
Publicado: (2011)

Autophagy and misfolded proteins in neurodegeneration
por: Metcalf, Daniel J., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_4l72nfqhq4sg39b126nuf2prkt