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GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK

The dynamic regulation of microtubules (MTs) during mitosis is critical for accurate chromosome segregation and genome stability. Cancer cell lines with hyperstabilized kinetochore MTs have increased segregation errors and elevated chromosomal instability (CIN), but the genetic defects responsible r...

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Detalles Bibliográficos
Autores principales:	Bendre, Shweta, Rondelet, Arnaud, Hall, Conrad, Schmidt, Nadine, Lin, Yu-Chih, Brouhard, Gary J., Bird, Alexander W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147003/ https://www.ncbi.nlm.nih.gov/pubmed/27881713 http://dx.doi.org/10.1083/jcb.201606081

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