Progranulin and the receptor tyrosine kinase EphA2, partners in crime?

Progranulin is a secreted protein with roles in tumorigenesis, inflammation, and neurobiology, but its signaling receptors have remained unclear. In this issue, Neill et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201603079) identify the tyrosine kinase EphA2 as a strong candidate for such...

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Detalles Bibliográficos
Autores principales: Chitramuthu, Babykumari, Bateman, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147006/
https://www.ncbi.nlm.nih.gov/pubmed/27903608
http://dx.doi.org/10.1083/jcb.201610097
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author Chitramuthu, Babykumari
Bateman, Andrew
author_facet Chitramuthu, Babykumari
Bateman, Andrew
author_sort Chitramuthu, Babykumari
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description Progranulin is a secreted protein with roles in tumorigenesis, inflammation, and neurobiology, but its signaling receptors have remained unclear. In this issue, Neill et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201603079) identify the tyrosine kinase EphA2 as a strong candidate for such a receptor, providing insight into progranulin and EphA2 signaling.
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spelling pubmed-51470062017-06-05 Progranulin and the receptor tyrosine kinase EphA2, partners in crime? Chitramuthu, Babykumari Bateman, Andrew J Cell Biol Commentary Progranulin is a secreted protein with roles in tumorigenesis, inflammation, and neurobiology, but its signaling receptors have remained unclear. In this issue, Neill et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201603079) identify the tyrosine kinase EphA2 as a strong candidate for such a receptor, providing insight into progranulin and EphA2 signaling. The Rockefeller University Press 2016-12-05 /pmc/articles/PMC5147006/ /pubmed/27903608 http://dx.doi.org/10.1083/jcb.201610097 Text en © 2016 Chitramuthu and Bateman This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Chitramuthu, Babykumari
Bateman, Andrew
Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
title Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
title_full Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
title_fullStr Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
title_full_unstemmed Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
title_short Progranulin and the receptor tyrosine kinase EphA2, partners in crime?
title_sort progranulin and the receptor tyrosine kinase epha2, partners in crime?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147006/
https://www.ncbi.nlm.nih.gov/pubmed/27903608
http://dx.doi.org/10.1083/jcb.201610097
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