Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility

Astrocytes have been implicated in epilepsy development, but their contribution is under debate. In this issue, Shen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605046) demonstrate that early postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and prom...

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Detalles Bibliográficos
Autores principales: Henneberger, Christian, Steinhäuser, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147008/
https://www.ncbi.nlm.nih.gov/pubmed/27881712
http://dx.doi.org/10.1083/jcb.201611078
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author Henneberger, Christian
Steinhäuser, Christian
author_facet Henneberger, Christian
Steinhäuser, Christian
author_sort Henneberger, Christian
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description Astrocytes have been implicated in epilepsy development, but their contribution is under debate. In this issue, Shen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605046) demonstrate that early postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and promote excitatory synaptogenesis, thereby increasing seizure susceptibility in young and adult mice.
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spelling pubmed-51470082017-06-05 Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility Henneberger, Christian Steinhäuser, Christian J Cell Biol Commentary Astrocytes have been implicated in epilepsy development, but their contribution is under debate. In this issue, Shen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605046) demonstrate that early postnatal inflammatory stimuli activate toll-like receptor 4 signaling in astrocytes and promote excitatory synaptogenesis, thereby increasing seizure susceptibility in young and adult mice. The Rockefeller University Press 2016-12-05 /pmc/articles/PMC5147008/ /pubmed/27881712 http://dx.doi.org/10.1083/jcb.201611078 Text en © 2016 Henneberger and Steinhauser This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Commentary
Henneberger, Christian
Steinhäuser, Christian
Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility
title Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility
title_full Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility
title_fullStr Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility
title_full_unstemmed Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility
title_short Astrocytic TLR4 at the crossroads of inflammation and seizure susceptibility
title_sort astrocytic tlr4 at the crossroads of inflammation and seizure susceptibility
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147008/
https://www.ncbi.nlm.nih.gov/pubmed/27881712
http://dx.doi.org/10.1083/jcb.201611078
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