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Dynamical compensation in physiological circuits

Biological systems can maintain constant steady‐state output despite variation in biochemical parameters, a property known as exact adaptation. Exact adaptation is achieved using integral feedback, an engineering strategy that ensures that the output of a system robustly tracks its desired value. Ho...

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Detalles Bibliográficos
Autores principales: Karin, Omer, Swisa, Avital, Glaser, Benjamin, Dor, Yuval, Alon, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147051/
https://www.ncbi.nlm.nih.gov/pubmed/27875241
http://dx.doi.org/10.15252/msb.20167216
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author Karin, Omer
Swisa, Avital
Glaser, Benjamin
Dor, Yuval
Alon, Uri
author_facet Karin, Omer
Swisa, Avital
Glaser, Benjamin
Dor, Yuval
Alon, Uri
author_sort Karin, Omer
collection PubMed
description Biological systems can maintain constant steady‐state output despite variation in biochemical parameters, a property known as exact adaptation. Exact adaptation is achieved using integral feedback, an engineering strategy that ensures that the output of a system robustly tracks its desired value. However, it is unclear how physiological circuits also keep their output dynamics precise—including the amplitude and response time to a changing input. Such robustness is crucial for endocrine and neuronal homeostatic circuits because they need to provide a precise dynamic response in the face of wide variation in the physiological parameters of their target tissues; how such circuits compensate their dynamics for unavoidable natural fluctuations in parameters is unknown. Here, we present a design principle that provides the desired robustness, which we call dynamical compensation (DC). We present a class of circuits that show DC by means of a nonlinear feedback loop in which the regulated variable controls the functional mass of the controlling endocrine or neuronal tissue. This mechanism applies to the control of blood glucose by insulin and explains several experimental observations on insulin resistance. We provide evidence that this mechanism may also explain compensation and organ size control in other physiological circuits.
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spelling pubmed-51470512016-12-12 Dynamical compensation in physiological circuits Karin, Omer Swisa, Avital Glaser, Benjamin Dor, Yuval Alon, Uri Mol Syst Biol Reports Biological systems can maintain constant steady‐state output despite variation in biochemical parameters, a property known as exact adaptation. Exact adaptation is achieved using integral feedback, an engineering strategy that ensures that the output of a system robustly tracks its desired value. However, it is unclear how physiological circuits also keep their output dynamics precise—including the amplitude and response time to a changing input. Such robustness is crucial for endocrine and neuronal homeostatic circuits because they need to provide a precise dynamic response in the face of wide variation in the physiological parameters of their target tissues; how such circuits compensate their dynamics for unavoidable natural fluctuations in parameters is unknown. Here, we present a design principle that provides the desired robustness, which we call dynamical compensation (DC). We present a class of circuits that show DC by means of a nonlinear feedback loop in which the regulated variable controls the functional mass of the controlling endocrine or neuronal tissue. This mechanism applies to the control of blood glucose by insulin and explains several experimental observations on insulin resistance. We provide evidence that this mechanism may also explain compensation and organ size control in other physiological circuits. John Wiley and Sons Inc. 2016-11-08 /pmc/articles/PMC5147051/ /pubmed/27875241 http://dx.doi.org/10.15252/msb.20167216 Text en © 2016 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the Creative Commons Attribution 4.0 (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reports
Karin, Omer
Swisa, Avital
Glaser, Benjamin
Dor, Yuval
Alon, Uri
Dynamical compensation in physiological circuits
title Dynamical compensation in physiological circuits
title_full Dynamical compensation in physiological circuits
title_fullStr Dynamical compensation in physiological circuits
title_full_unstemmed Dynamical compensation in physiological circuits
title_short Dynamical compensation in physiological circuits
title_sort dynamical compensation in physiological circuits
topic Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147051/
https://www.ncbi.nlm.nih.gov/pubmed/27875241
http://dx.doi.org/10.15252/msb.20167216
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