Single‐cell sequencing maps gene expression to mutational phylogenies in PDGF‐ and EGF‐driven gliomas

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Epidermal growth factor (EGF) and platelet‐derived growth factor (PDGF) receptors are frequently amplified and/or possess gain‐of‐function mutations in GBM. However, clinical trials of tyrosine‐kinase inhibi...

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Detalles Bibliográficos
Autores principales: Müller, Sören, Liu, Siyuan John, Di Lullo, Elizabeth, Malatesta, Martina, Pollen, Alex A, Nowakowski, Tomasz J, Kohanbash, Gary, Aghi, Manish, Kriegstein, Arnold R, Lim, Daniel A, Diaz, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147052/
https://www.ncbi.nlm.nih.gov/pubmed/27888226
http://dx.doi.org/10.15252/msb.20166969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147052/
https://www.ncbi.nlm.nih.gov/pubmed/27888226
http://dx.doi.org/10.15252/msb.20166969

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