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Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer

The double-stranded RNA-binding protein TARBP2 has been suggested to act as an upstream regulator of breast cancer metastasis by destabilizing transcripts of the possible metastasis suppressors amyloid precursor protein (APP) and ZNF395. We examined this hypothesis by immunostaining of TARBP2, APP,...

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Autores principales: Oi, Ryoko, Koizumi, Hirotaka, Maeda, Ichiro, Noguchi, Akira, Tatsunami, Shinobu, Iwatani, Tsuguo, Kawamoto, Hisanori, Tsugawa, Koichiro, Takagi, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147454/
https://www.ncbi.nlm.nih.gov/pubmed/27980417
http://dx.doi.org/10.4137/BCBCR.S40820
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author Oi, Ryoko
Koizumi, Hirotaka
Maeda, Ichiro
Noguchi, Akira
Tatsunami, Shinobu
Iwatani, Tsuguo
Kawamoto, Hisanori
Tsugawa, Koichiro
Takagi, Masayuki
author_facet Oi, Ryoko
Koizumi, Hirotaka
Maeda, Ichiro
Noguchi, Akira
Tatsunami, Shinobu
Iwatani, Tsuguo
Kawamoto, Hisanori
Tsugawa, Koichiro
Takagi, Masayuki
author_sort Oi, Ryoko
collection PubMed
description The double-stranded RNA-binding protein TARBP2 has been suggested to act as an upstream regulator of breast cancer metastasis by destabilizing transcripts of the possible metastasis suppressors amyloid precursor protein (APP) and ZNF395. We examined this hypothesis by immunostaining of TARBP2, APP, and ZNF395 in 200 breast cancer specimens using tissue microarrays and analyzed the relationships between expression levels and clinicopathological parameters and prognosis. Increased TARBP2 overexpression was associated with shorter overall survival and disease-free survival, and increased but not reduced APP expression correlated with lower overall survival and disease-free survival. ZNF395 expression levels had no prognostic value, but reduced expression correlated with reduced lymph node metastasis. There was no significant relationship between TARBP2 overexpression and reduced APP and/or ZNF395 expression. Patients with tumors with higher TARBP2 or APP expression had unfavorable prognoses. Although reduced ZNF395 expression was significantly related to reduced lymph node metastasis, further studies are needed to clarify the role of TARBP2/APP/ZNF395 in breast cancer.
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spelling pubmed-51474542016-12-15 Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer Oi, Ryoko Koizumi, Hirotaka Maeda, Ichiro Noguchi, Akira Tatsunami, Shinobu Iwatani, Tsuguo Kawamoto, Hisanori Tsugawa, Koichiro Takagi, Masayuki Breast Cancer (Auckl) Original Research The double-stranded RNA-binding protein TARBP2 has been suggested to act as an upstream regulator of breast cancer metastasis by destabilizing transcripts of the possible metastasis suppressors amyloid precursor protein (APP) and ZNF395. We examined this hypothesis by immunostaining of TARBP2, APP, and ZNF395 in 200 breast cancer specimens using tissue microarrays and analyzed the relationships between expression levels and clinicopathological parameters and prognosis. Increased TARBP2 overexpression was associated with shorter overall survival and disease-free survival, and increased but not reduced APP expression correlated with lower overall survival and disease-free survival. ZNF395 expression levels had no prognostic value, but reduced expression correlated with reduced lymph node metastasis. There was no significant relationship between TARBP2 overexpression and reduced APP and/or ZNF395 expression. Patients with tumors with higher TARBP2 or APP expression had unfavorable prognoses. Although reduced ZNF395 expression was significantly related to reduced lymph node metastasis, further studies are needed to clarify the role of TARBP2/APP/ZNF395 in breast cancer. Libertas Academica 2016-12-08 /pmc/articles/PMC5147454/ /pubmed/27980417 http://dx.doi.org/10.4137/BCBCR.S40820 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 license.
spellingShingle Original Research
Oi, Ryoko
Koizumi, Hirotaka
Maeda, Ichiro
Noguchi, Akira
Tatsunami, Shinobu
Iwatani, Tsuguo
Kawamoto, Hisanori
Tsugawa, Koichiro
Takagi, Masayuki
Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer
title Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer
title_full Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer
title_fullStr Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer
title_full_unstemmed Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer
title_short Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer
title_sort clinicopathological significance of tarbp2, app, and znf395 in breast cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147454/
https://www.ncbi.nlm.nih.gov/pubmed/27980417
http://dx.doi.org/10.4137/BCBCR.S40820
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