Should hydrogen therapy be included in a musculoskeletal medicine routine?

Molecular hydrogen (H (2)) has recently been recognized as a potential novel therapeutic agent in biomedicine. Initially proposed to be a possible treatment for certain types of neuromuscular disorders, cardio-metabolic diseases and cancer, H (2) improved clinical end-points and surrogate markers in several clinical trials, mainly acting as an anti-inflammatory agent and powerful antioxidant. In this paper, the medicinal properties of H (2) in musculoskeletal medicine are discussed with the aim to provide an updated and practical overview for health professionals working in this field.