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A decade after SARS: strategies for controlling emerging coronaviruses

Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), both of which cause acute respiratory distress syndrome (ARDS) and are associated with high mortality rate...

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Detalles Bibliográficos
Autores principales: Graham, Rachel L., Donaldson, Eric F., Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147543/
https://www.ncbi.nlm.nih.gov/pubmed/24217413
http://dx.doi.org/10.1038/nrmicro3143
Descripción
Sumario:Two novel coronaviruses have emerged in humans in the twenty-first century: severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), both of which cause acute respiratory distress syndrome (ARDS) and are associated with high mortality rates. There are no clinically approved vaccines or antiviral drugs available for either of these infections; thus, the development of effective therapeutic and preventive strategies that can be readily applied to new emergent strains is a research priority. In this Review, we describe the emergence and identification of novel human coronaviruses over the past 10 years, discuss their key biological features, including tropism and receptor use, and summarize approaches for developing broadly effective vaccines. SUPPLEMENTARY INFORMATION: The online version of this article (doi:10.1038/nrmicro3143) contains supplementary material, which is available to authorized users.