High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines

Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and compound-resist...

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Detalles Bibliográficos
Autores principales: Filipuzzi, Ireos, Cotesta, Simona, Perruccio, Francesca, Knapp, Britta, Fu, Yue, Studer, Christian, Pries, Verena, Riedl, Ralph, Helliwell, Stephen B., Petrovic, Katarina T., Movva, N. Rao, Sanglard, Dominique, Tao, Jianshi, Hoepfner, Dominic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147771/
https://www.ncbi.nlm.nih.gov/pubmed/27855158
http://dx.doi.org/10.1371/journal.pgen.1006374

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