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Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6

BACKGROUND AND AIMS: Growth hormone (GH) not only supports hepatic metabolism but also protects against hepatocyte cell death. Hnf6 (or Oc1) belonging to the Onecut family of hepatocyte transcription factors known to regulate differentiated hepatic function, is a GH-responsive gene. We evaluate if G...

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Detalles Bibliográficos
Autores principales: Wang, Kewei, Wang, Minhua, Gannon, Maureen, Holterman, AiXuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147851/
https://www.ncbi.nlm.nih.gov/pubmed/27936029
http://dx.doi.org/10.1371/journal.pone.0167085