A (99m)Tc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives

A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with (99m)Tc was developed, and its utility for creating probes to image bone metabolism and bacterial infection using both active and pretargeting strategies was demonstrated. The (99m)Tc-labelled HYNIC-tetrazin...

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Detalles Bibliográficos
Autores principales: Vito, Alyssa, Alarabi, Hussain, Czorny, Shannon, Beiraghi, Omid, Kent, Jeff, Janzen, Nancy, Genady, Afaf R., Alkarmi, Salma A., Rathmann, Stephanie, Naperstkow, Zoya, Blacker, Megan, Llano, Lisset, Berti, Paul J., Valliant, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147877/
https://www.ncbi.nlm.nih.gov/pubmed/27936007
http://dx.doi.org/10.1371/journal.pone.0167425

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