Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization

Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal...

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Detalles Bibliográficos
Autores principales: Ramratnam, Mohun, Salama, Guy, Sharma, Ravi K., Wang, David Wen Rui, Smith, Stephen H., Banerjee, Sanjay K., Huang, Xueyin N., Gifford, Lindsey M., Pruce, Michele L., Gabris, Bethann E., Saba, Samir, Shroff, Sanjeev G., Ahmad, Ferhaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147943/
https://www.ncbi.nlm.nih.gov/pubmed/27936050
http://dx.doi.org/10.1371/journal.pone.0167681

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