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Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice

Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2(Akita/wt) mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP...

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Autores principales: Guihard, Pierre J., Yao, Jiayi, Blazquez-Medela, Ana M., Iruela-Arispe, Luisa, Boström, Kristina I., Yao, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148029/
https://www.ncbi.nlm.nih.gov/pubmed/27936229
http://dx.doi.org/10.1371/journal.pone.0167936
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author Guihard, Pierre J.
Yao, Jiayi
Blazquez-Medela, Ana M.
Iruela-Arispe, Luisa
Boström, Kristina I.
Yao, Yucheng
author_facet Guihard, Pierre J.
Yao, Jiayi
Blazquez-Medela, Ana M.
Iruela-Arispe, Luisa
Boström, Kristina I.
Yao, Yucheng
author_sort Guihard, Pierre J.
collection PubMed
description Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2(Akita/wt) mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries.
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spelling pubmed-51480292016-12-28 Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice Guihard, Pierre J. Yao, Jiayi Blazquez-Medela, Ana M. Iruela-Arispe, Luisa Boström, Kristina I. Yao, Yucheng PLoS One Research Article Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2(Akita/wt) mouse, and show that induction of sex determining region Y-box 2 (Sox2) is a mediator of excess BMP signaling that results in activation of EndMTs and increased vascular calcification. We also find an induction of a complex of serine proteases in the diabetic endothelium, required for the up-regulation of Sox2. Our results suggest that EndMTs contribute to vascular calcification in diabetic arteries. Public Library of Science 2016-12-09 /pmc/articles/PMC5148029/ /pubmed/27936229 http://dx.doi.org/10.1371/journal.pone.0167936 Text en © 2016 Guihard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Guihard, Pierre J.
Yao, Jiayi
Blazquez-Medela, Ana M.
Iruela-Arispe, Luisa
Boström, Kristina I.
Yao, Yucheng
Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
title Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
title_full Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
title_fullStr Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
title_full_unstemmed Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
title_short Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
title_sort endothelial-mesenchymal transition in vascular calcification of ins2(akita/+) mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148029/
https://www.ncbi.nlm.nih.gov/pubmed/27936229
http://dx.doi.org/10.1371/journal.pone.0167936
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