Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

The survival of Waldenstrom macroglobulinemia (WM) tumor cells hinges on aberrant B-cell receptor (BCR) and MYD88 signaling. WM cells upregulate the proteasome function to sustain the BCR-driven growth while maintaining homeostasis. Clinically, two treatment strategies are used to disrupt these comp...

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Detalles Bibliográficos
Autores principales: Paulus, A, Akhtar, S, Caulfield, T R, Samuel, K, Yousaf, H, Bashir, Y, Paulus, S M, Tran, D, Hudec, R, Cogen, D, Jiang, J, Edenfield, B, Novak, A, Ansell, S M, Witzig, T, Martin, P, Coleman, M, Roy, V, Ailawadhi, S, Chitta, K, Linder, S, Chanan-Khan, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148058/
https://www.ncbi.nlm.nih.gov/pubmed/27813535
http://dx.doi.org/10.1038/bcj.2016.93

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