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The NS4A Cofactor Dependent Enhancement of HCV NS3 Protease Activity Correlates with a 4D Geometrical Measure of the Catalytic Triad Region

We are developing a 4D computational methodology, based on 3D structure modeling and molecular dynamics simulation, to analyze the active site of HCV NS3 proteases, in relation to their catalytic activity. In our previous work, the 4D analyses of the interactions between the catalytic triad residues...

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Detalles Bibliográficos
Autores principales:	Hamad, Hamzah A., Thurston, Jeremy, Teague, Thomas, Ackad, Edward, Yousef, Mohammad S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148068/ https://www.ncbi.nlm.nih.gov/pubmed/27936126 http://dx.doi.org/10.1371/journal.pone.0168002

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