The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

Lipoprotein lipase (LPL) undergoes spontaneous inactivation via global unfolding and this unfolding is prevented by GPIHBP1 (Mysling et al., 2016). We now show: (1) that ANGPTL4 inactivates LPL by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 renders LPL largely refra...

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Detalles Bibliográficos
Autores principales: Mysling, Simon, Kristensen, Kristian Kølby, Larsson, Mikael, Kovrov, Oleg, Bensadouen, André, Jørgensen, Thomas JD, Olivecrona, Gunilla, Young, Stephen G, Ploug, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148603/
https://www.ncbi.nlm.nih.gov/pubmed/27929370
http://dx.doi.org/10.7554/eLife.20958

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