Cargando…

Nephrotoxicity of methadone: a systematic review

BACKGROUND: Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of opioid analgesics, including methadone, is that of nephrotoxicity. Opioids can...

Descripción completa

Detalles Bibliográficos
Autores principales: Alinejad, Samira, Ghaemi, Kazem, Abdollahi, Mohammad, Mehrpour, Omid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148752/
https://www.ncbi.nlm.nih.gov/pubmed/28018795
http://dx.doi.org/10.1186/s40064-016-3757-1
_version_ 1782473873796628480
author Alinejad, Samira
Ghaemi, Kazem
Abdollahi, Mohammad
Mehrpour, Omid
author_facet Alinejad, Samira
Ghaemi, Kazem
Abdollahi, Mohammad
Mehrpour, Omid
author_sort Alinejad, Samira
collection PubMed
description BACKGROUND: Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of opioid analgesics, including methadone, is that of nephrotoxicity. Opioids can have an effect on renal function through several different mechanisms. METHODS: We searched common bibliographical databases for the terms methadone, toxicity, poisoning, kidney, renal, and nephrotoxicity and summarize our findings in this review. RESULTS: Methadone can have both direct and indirect effects on the kidney. These effects include rhabdomyolysis (leading to acute kidney injury), volumetric changes, renal lipidosis and amyloidosis, kidney growth during pregnancy, and kidney transplant rejection. CONCLUSION: Improved understanding of the effects of methadone on kidney function can promote safer and more confident use of the drug.
format Online
Article
Text
id pubmed-5148752
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-51487522016-12-23 Nephrotoxicity of methadone: a systematic review Alinejad, Samira Ghaemi, Kazem Abdollahi, Mohammad Mehrpour, Omid Springerplus Review BACKGROUND: Methadone is commonly administered for chronic pain relief and treatment of opioid dependence. Concurrent with its increased consumption, toxicities and fatalities have increased. One of the adverse effects of opioid analgesics, including methadone, is that of nephrotoxicity. Opioids can have an effect on renal function through several different mechanisms. METHODS: We searched common bibliographical databases for the terms methadone, toxicity, poisoning, kidney, renal, and nephrotoxicity and summarize our findings in this review. RESULTS: Methadone can have both direct and indirect effects on the kidney. These effects include rhabdomyolysis (leading to acute kidney injury), volumetric changes, renal lipidosis and amyloidosis, kidney growth during pregnancy, and kidney transplant rejection. CONCLUSION: Improved understanding of the effects of methadone on kidney function can promote safer and more confident use of the drug. Springer International Publishing 2016-12-09 /pmc/articles/PMC5148752/ /pubmed/28018795 http://dx.doi.org/10.1186/s40064-016-3757-1 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Alinejad, Samira
Ghaemi, Kazem
Abdollahi, Mohammad
Mehrpour, Omid
Nephrotoxicity of methadone: a systematic review
title Nephrotoxicity of methadone: a systematic review
title_full Nephrotoxicity of methadone: a systematic review
title_fullStr Nephrotoxicity of methadone: a systematic review
title_full_unstemmed Nephrotoxicity of methadone: a systematic review
title_short Nephrotoxicity of methadone: a systematic review
title_sort nephrotoxicity of methadone: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148752/
https://www.ncbi.nlm.nih.gov/pubmed/28018795
http://dx.doi.org/10.1186/s40064-016-3757-1
work_keys_str_mv AT alinejadsamira nephrotoxicityofmethadoneasystematicreview
AT ghaemikazem nephrotoxicityofmethadoneasystematicreview
AT abdollahimohammad nephrotoxicityofmethadoneasystematicreview
AT mehrpouromid nephrotoxicityofmethadoneasystematicreview