From theory to bench confirmation or from bench to theory

In this commentary, the authors discuss two possible approaches in experimental studies. The first approach is to replicate an experimentation in order to confirm or not previously published results. The second one is more theoretical and consists in estimating the expected effect of all the compone...

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Detalles Bibliográficos
Autores principales: Demiselle, Julien, Tillmans, Frauke, Koch, Andreas, Radermacher, Peter, Asfar, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148755/
https://www.ncbi.nlm.nih.gov/pubmed/27943111
http://dx.doi.org/10.1186/s40635-016-0113-2
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author Demiselle, Julien
Tillmans, Frauke
Koch, Andreas
Radermacher, Peter
Asfar, Pierre
author_facet Demiselle, Julien
Tillmans, Frauke
Koch, Andreas
Radermacher, Peter
Asfar, Pierre
author_sort Demiselle, Julien
collection PubMed
description In this commentary, the authors discuss two possible approaches in experimental studies. The first approach is to replicate an experimentation in order to confirm or not previously published results. The second one is more theoretical and consists in estimating the expected effect of all the components of the problem. When theoretical calculations suggest a theoretical failure that contradicts previous published results, investigators are between a rock and a hard place. Indeed, how can already published data and theoretical likelihood of failure be reconciled?
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spelling pubmed-51487552016-12-23 From theory to bench confirmation or from bench to theory Demiselle, Julien Tillmans, Frauke Koch, Andreas Radermacher, Peter Asfar, Pierre Intensive Care Med Exp Letter to the Editor In this commentary, the authors discuss two possible approaches in experimental studies. The first approach is to replicate an experimentation in order to confirm or not previously published results. The second one is more theoretical and consists in estimating the expected effect of all the components of the problem. When theoretical calculations suggest a theoretical failure that contradicts previous published results, investigators are between a rock and a hard place. Indeed, how can already published data and theoretical likelihood of failure be reconciled? Springer International Publishing 2016-12-09 /pmc/articles/PMC5148755/ /pubmed/27943111 http://dx.doi.org/10.1186/s40635-016-0113-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Letter to the Editor
Demiselle, Julien
Tillmans, Frauke
Koch, Andreas
Radermacher, Peter
Asfar, Pierre
From theory to bench confirmation or from bench to theory
title From theory to bench confirmation or from bench to theory
title_full From theory to bench confirmation or from bench to theory
title_fullStr From theory to bench confirmation or from bench to theory
title_full_unstemmed From theory to bench confirmation or from bench to theory
title_short From theory to bench confirmation or from bench to theory
title_sort from theory to bench confirmation or from bench to theory
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148755/
https://www.ncbi.nlm.nih.gov/pubmed/27943111
http://dx.doi.org/10.1186/s40635-016-0113-2
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