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Genetic polymorphisms of enzyme proteins and transporters related to methotrexate response and pharmacokinetics in a Japanese population

BACKGROUND: Methotrexate (MTX) is currently the anchor drug widely used worldwide in the treatment of rheumatoid arthritis (RA). However, the therapeutic response to MTX has been shown to vary widely among individuals, genders and ethnic groups. The reason for this has been not clarified but it is c...

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Autores principales:	Hashiguchi, Masayuki, Shimizu, Mikiko, Hakamata, Jun, Tsuru, Tomomi, Tanaka, Takanori, Suzaki, Midori, Miyawaki, Kumika, Chiyoda, Takeshi, Takeuchi, Osamu, Hiratsuka, Jiro, Irie, Shin, Maruyama, Junya, Mochizuki, Mayumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148839/ https://www.ncbi.nlm.nih.gov/pubmed/27980801 http://dx.doi.org/10.1186/s40780-016-0069-0

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