Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

BACKGROUND AND AIMS: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action o...

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Detalles Bibliográficos
Autores principales: Duarte, Tiago L., Caldas, Carolina, Santos, Ana G., Silva-Gomes, Sandro, Santos-Gonçalves, Andreia, Martins, Maria João, Porto, Graça, Lopes, José Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149069/
https://www.ncbi.nlm.nih.gov/pubmed/27936457
http://dx.doi.org/10.1016/j.redox.2016.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149069/
https://www.ncbi.nlm.nih.gov/pubmed/27936457
http://dx.doi.org/10.1016/j.redox.2016.11.013

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