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The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients

BACKGROUND: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed f...

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Autores principales: Othman, Nagwa-Abdelhamid, Shaker, Olfat-Gamil, Elshenawy, Hanaa-Mohamed, Abd-Elmoniem, Wessam, Eldin, Amany-Mohy, Fakhr, Mariam-Yehia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149093/
https://www.ncbi.nlm.nih.gov/pubmed/27957272
http://dx.doi.org/10.4317/jced.52665
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author Othman, Nagwa-Abdelhamid
Shaker, Olfat-Gamil
Elshenawy, Hanaa-Mohamed
Abd-Elmoniem, Wessam
Eldin, Amany-Mohy
Fakhr, Mariam-Yehia
author_facet Othman, Nagwa-Abdelhamid
Shaker, Olfat-Gamil
Elshenawy, Hanaa-Mohamed
Abd-Elmoniem, Wessam
Eldin, Amany-Mohy
Fakhr, Mariam-Yehia
author_sort Othman, Nagwa-Abdelhamid
collection PubMed
description BACKGROUND: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed for management of symptomatic OLP. This study was carried out to evaluate the effect of topical steroids as well as laser on the clinical signs and symptoms detected by reticular, atrophic, erosive score (RAE score) and tumor necrosis factor- α (TNF-α) level in the serum of patients with symptomatic OLP. MATERIAL AND METHODS: The study was conducted on twenty-four patients (18 females and 6 males) with symptomatic OLP that were allocated into two groups. Each included twelve patients. The first group treated either with diode laser (970nm SIROLaser Advance class IIIb, SIRONA The Dental Company, Germany) twice weekly with maximum of ten sessions while the second group were treated with topical corticosteroids (0.1% triamcinolone acetonide orabase, Kenacort-A Orabase Pomad, DEVA HOLDING A.Ș, Istanbul, Turkey) for four weeks. RESULTS: Corticosteroids group showed less clinical signs and symptoms of reticular, atrophic, erosive RAE score (p=0.02) and TNF-α serum level (p=0.028) than diode laser group with no reported therapy side effects or complications in any of the treated patients. CONCLUSIONS: Topical steroids reduce pain, reticular, atrophic, erosive RAE score and TNF-α serum level more than laser treatment. Moreover, laser treatment can be used as an alternative treatment when steroids are contraindicated for the treatment of symptomatic OLP. Key words:Oral lichen planus, diode laser, topical steroid, RAE score, TNF-α.
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spelling pubmed-51490932016-12-12 The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients Othman, Nagwa-Abdelhamid Shaker, Olfat-Gamil Elshenawy, Hanaa-Mohamed Abd-Elmoniem, Wessam Eldin, Amany-Mohy Fakhr, Mariam-Yehia J Clin Exp Dent Research BACKGROUND: Oral lichen planus (OLP) is a common chronic inflammatory mucosal disease with a multifactorial etiology. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+T cells trigger apoptosis of the basal cells of oral epithelium. Various treatment regimens have been employed for management of symptomatic OLP. This study was carried out to evaluate the effect of topical steroids as well as laser on the clinical signs and symptoms detected by reticular, atrophic, erosive score (RAE score) and tumor necrosis factor- α (TNF-α) level in the serum of patients with symptomatic OLP. MATERIAL AND METHODS: The study was conducted on twenty-four patients (18 females and 6 males) with symptomatic OLP that were allocated into two groups. Each included twelve patients. The first group treated either with diode laser (970nm SIROLaser Advance class IIIb, SIRONA The Dental Company, Germany) twice weekly with maximum of ten sessions while the second group were treated with topical corticosteroids (0.1% triamcinolone acetonide orabase, Kenacort-A Orabase Pomad, DEVA HOLDING A.Ș, Istanbul, Turkey) for four weeks. RESULTS: Corticosteroids group showed less clinical signs and symptoms of reticular, atrophic, erosive RAE score (p=0.02) and TNF-α serum level (p=0.028) than diode laser group with no reported therapy side effects or complications in any of the treated patients. CONCLUSIONS: Topical steroids reduce pain, reticular, atrophic, erosive RAE score and TNF-α serum level more than laser treatment. Moreover, laser treatment can be used as an alternative treatment when steroids are contraindicated for the treatment of symptomatic OLP. Key words:Oral lichen planus, diode laser, topical steroid, RAE score, TNF-α. Medicina Oral S.L. 2016-12-01 /pmc/articles/PMC5149093/ /pubmed/27957272 http://dx.doi.org/10.4317/jced.52665 Text en Copyright: © 2016 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Othman, Nagwa-Abdelhamid
Shaker, Olfat-Gamil
Elshenawy, Hanaa-Mohamed
Abd-Elmoniem, Wessam
Eldin, Amany-Mohy
Fakhr, Mariam-Yehia
The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients
title The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients
title_full The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients
title_fullStr The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients
title_full_unstemmed The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients
title_short The effect of diode laser and topical steroid on serum level of TNF-alpha in oral lichen planus patients
title_sort effect of diode laser and topical steroid on serum level of tnf-alpha in oral lichen planus patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149093/
https://www.ncbi.nlm.nih.gov/pubmed/27957272
http://dx.doi.org/10.4317/jced.52665
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