Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase

Human Gb3/CD77 synthase (α1,4-galactosyltransferase) is the only known glycosyltransferase that changes acceptor specificity because of a point mutation. The enzyme, encoded by A4GALT locus, is responsible for biosynthesis of Gal(α1–4)Gal moiety in Gb3 (CD77, P(k) antigen) and P1 glycosphingolipids....

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Detalles Bibliográficos
Autores principales: Kaczmarek, Radoslaw, Mikolajewicz, Katarzyna, Szymczak, Katarzyna, Duk, Maria, Majorczyk, Edyta, Krop-Watorek, Anna, Buczkowska, Anna, Czerwinski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149393/
https://www.ncbi.nlm.nih.gov/pubmed/27538840
http://dx.doi.org/10.1007/s10719-016-9716-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149393/
https://www.ncbi.nlm.nih.gov/pubmed/27538840
http://dx.doi.org/10.1007/s10719-016-9716-9

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