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Evaluation of an amino acid residue critical for the specificity and activity of human Gb3/CD77 synthase
Human Gb3/CD77 synthase (α1,4-galactosyltransferase) is the only known glycosyltransferase that changes acceptor specificity because of a point mutation. The enzyme, encoded by A4GALT locus, is responsible for biosynthesis of Gal(α1–4)Gal moiety in Gb3 (CD77, P(k) antigen) and P1 glycosphingolipids....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149393/ https://www.ncbi.nlm.nih.gov/pubmed/27538840 http://dx.doi.org/10.1007/s10719-016-9716-9 |