Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke

Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks,...

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Autores principales: Lin, Jinpei, Xu, Fei, Wang, Genfa, Kong, Lingwen, Luo, Qingli, Lv, Yvbao, Liu, Jiaqi, Wei, Ying, Li, Lulu, Zhang, Hongying, Dong, Jingcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149678/
https://www.ncbi.nlm.nih.gov/pubmed/28003846
http://dx.doi.org/10.1155/2016/1698379
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author Lin, Jinpei
Xu, Fei
Wang, Genfa
Kong, Lingwen
Luo, Qingli
Lv, Yvbao
Liu, Jiaqi
Wei, Ying
Li, Lulu
Zhang, Hongying
Dong, Jingcheng
author_facet Lin, Jinpei
Xu, Fei
Wang, Genfa
Kong, Lingwen
Luo, Qingli
Lv, Yvbao
Liu, Jiaqi
Wei, Ying
Li, Lulu
Zhang, Hongying
Dong, Jingcheng
author_sort Lin, Jinpei
collection PubMed
description Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.
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spelling pubmed-51496782016-12-21 Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke Lin, Jinpei Xu, Fei Wang, Genfa Kong, Lingwen Luo, Qingli Lv, Yvbao Liu, Jiaqi Wei, Ying Li, Lulu Zhang, Hongying Dong, Jingcheng Evid Based Complement Alternat Med Research Article Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism. Hindawi Publishing Corporation 2016 2016-11-28 /pmc/articles/PMC5149678/ /pubmed/28003846 http://dx.doi.org/10.1155/2016/1698379 Text en Copyright © 2016 Jinpei Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Jinpei
Xu, Fei
Wang, Genfa
Kong, Lingwen
Luo, Qingli
Lv, Yvbao
Liu, Jiaqi
Wei, Ying
Li, Lulu
Zhang, Hongying
Dong, Jingcheng
Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke
title Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke
title_full Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke
title_fullStr Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke
title_full_unstemmed Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke
title_short Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke
title_sort paeoniflorin attenuated oxidative stress in rat copd model induced by cigarette smoke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149678/
https://www.ncbi.nlm.nih.gov/pubmed/28003846
http://dx.doi.org/10.1155/2016/1698379
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