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Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk
Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149697/ https://www.ncbi.nlm.nih.gov/pubmed/28003912 http://dx.doi.org/10.1155/2016/3915703 |
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author | Wang, Junjie Tang, Yingying Zhang, Tianhong Cui, Huiru Xu, Lihua Zeng, Botao Li, Yu Li, Gaiying Li, Chunbo Liu, Hui Lu, Zheng Zhang, Jianye Wang, Jijun |
author_facet | Wang, Junjie Tang, Yingying Zhang, Tianhong Cui, Huiru Xu, Lihua Zeng, Botao Li, Yu Li, Gaiying Li, Chunbo Liu, Hui Lu, Zheng Zhang, Jianye Wang, Jijun |
author_sort | Wang, Junjie |
collection | PubMed |
description | Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with first-episode schizophrenia (FES), and 23 healthy controls (HC) were enrolled. In vivo GABA and glutamate+glutamine (Glx) levels in the medial prefrontal cortex were measured using proton magnetic resonance spectroscopy. Medial prefrontal GABA and Glx levels in FES patients were significantly lower than those in HC and UHR, respectively. GABA and Glx levels in UHR were comparable with those in HC. In each group, there was a positive correlation between GABA and Glx levels. Reduced medial prefrontal GABA and Glx levels thus may play an important role in the early stages of schizophrenia. |
format | Online Article Text |
id | pubmed-5149697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51496972016-12-21 Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk Wang, Junjie Tang, Yingying Zhang, Tianhong Cui, Huiru Xu, Lihua Zeng, Botao Li, Yu Li, Gaiying Li, Chunbo Liu, Hui Lu, Zheng Zhang, Jianye Wang, Jijun Neural Plast Research Article Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with first-episode schizophrenia (FES), and 23 healthy controls (HC) were enrolled. In vivo GABA and glutamate+glutamine (Glx) levels in the medial prefrontal cortex were measured using proton magnetic resonance spectroscopy. Medial prefrontal GABA and Glx levels in FES patients were significantly lower than those in HC and UHR, respectively. GABA and Glx levels in UHR were comparable with those in HC. In each group, there was a positive correlation between GABA and Glx levels. Reduced medial prefrontal GABA and Glx levels thus may play an important role in the early stages of schizophrenia. Hindawi Publishing Corporation 2016 2016-11-28 /pmc/articles/PMC5149697/ /pubmed/28003912 http://dx.doi.org/10.1155/2016/3915703 Text en Copyright © 2016 Junjie Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Junjie Tang, Yingying Zhang, Tianhong Cui, Huiru Xu, Lihua Zeng, Botao Li, Yu Li, Gaiying Li, Chunbo Liu, Hui Lu, Zheng Zhang, Jianye Wang, Jijun Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk |
title | Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk |
title_full | Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk |
title_fullStr | Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk |
title_full_unstemmed | Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk |
title_short | Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk |
title_sort | reduced γ-aminobutyric acid and glutamate+glutamine levels in drug-naïve patients with first-episode schizophrenia but not in those at ultrahigh risk |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149697/ https://www.ncbi.nlm.nih.gov/pubmed/28003912 http://dx.doi.org/10.1155/2016/3915703 |
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