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Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature

T-Acute Lymphoblastic Leukemia (T-ALL) remains a subgroup of pediatric ALL, with a lower response to standard chemotherapy. Some recent studies established the fundamental role of epigenetic aberrations such as DNA hypermethylation, to influence patients' outcome and response to chemotherapy. M...

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Detalles Bibliográficos
Autores principales:	Serravalle, Salvatore, Bertuccio, Salvatore N., Astolfi, Annalisa, Melchionda, Fraia, Pession, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150123/ https://www.ncbi.nlm.nih.gov/pubmed/28003999 http://dx.doi.org/10.1155/2016/1985750

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