Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex

Type-I interferons (IFNs) play a key role in the immune defences against viral and bacterial infections, and in cancer immunosurveillance. We have established that clathrin-dependent endocytosis of the type-I interferon (IFN-α/β) receptor (IFNAR) is required for JAK/STAT signalling. Here we show tha...

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Detalles Bibliográficos
Autores principales: Chmiest, Daniela, Sharma, Nanaocha, Zanin, Natacha, Viaris de Lesegno, Christine, Shafaq-Zadah, Massiullah, Sibut, Vonick, Dingli, Florent, Hupé, Philippe, Wilmes, Stephan, Piehler, Jacob, Loew, Damarys, Johannes, Ludger, Schreiber, Gideon, Lamaze, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150223/
https://www.ncbi.nlm.nih.gov/pubmed/27917878
http://dx.doi.org/10.1038/ncomms13476

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