Cargando…

Antimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway

1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is the first committed enzyme in the 2-methyl-D-erythritol 4-phosphate (MEP) terpenoid biosynthetic pathway and is also a validated antimicrobial target. Theaflavins, which are polyphenolic compounds isolated from fermented tea, possess a wide ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hui, Xian, Yue, Qiao, Zhang, Dan-Dan, Li, Heng, Yang, Shao-Qing, Gao, Wen-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150241/ https://www.ncbi.nlm.nih.gov/pubmed/27941853 http://dx.doi.org/10.1038/srep38945

Ejemplares similares

Kinetic Characterization and Phosphoregulation of the Francisella tularensis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)
por: Jawaid, Safdar, et al.
Publicado: (2009)

Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)
por: Haymond, Amanda, et al.
Publicado: (2014)

Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from Plasmodium falciparum
por: Roca, Carlota, et al.
Publicado: (2022)

Inhibitory Activity of Plant Essential Oils against E. coli 1-Deoxy-d-xylulose-5-phosphate reductoisomerase
por: Yan, Ge, et al.
Publicado: (2019)

Molecular Cloning and Functional Analysis of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase from Santalum album
por: Zhang, Yueya, et al.
Publicado: (2021)

Differential roles of Cassia tora 1-deoxy-D-xylulose-5-phosphate synthase and 1-deoxy-D-xylulose-5-phosphate reductoisomerase in trade-off between plant growth and drought tolerance
por: Tian, Chunyao, et al.
Publicado: (2023)

Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin
por: Kholodar, Svetlana A., et al.
Publicado: (2014)

In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria
por: Wadood, Abdul, et al.
Publicado: (2016)

Characterization and Inhibition of 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase: A Promising Drug Target in Acinetobacter baumannii and Klebsiella pneumoniae
por: Ball, Haley S., et al.
Publicado: (2021)

MEP pathway products allosterically promote monomerization of deoxy-D-xylulose-5-phosphate synthase to feedback-regulate their supply
por: Di, Xueni, et al.
Publicado: (2022)

Synthetic Fosmidomycin Analogues with Altered Chelating Moieties Do Not Inhibit 1-Deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum Growth In Vitro
por: Chofor, René, et al.
Publicado: (2014)

Synthesis of Functionalized Cinnamaldehyde Derivatives by an Oxidative Heck Reaction and Their Use as Starting Materials for Preparation of Mycobacterium tuberculosis 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Inhibitors
por: Nordqvist, Anneli, et al.
Publicado: (2011)

Virtual Screening of compounds to 1-deoxy-Dxylulose 5-phosphate reductoisomerase (DXR) from Plasmodium falciparum
por: Chaudhary, Kamal Kumar, et al.
Publicado: (2014)

Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans
por: Handa, Sumit, et al.
Publicado: (2018)

Functional Characterization of the 1-Deoxy-D-Xylulose 5-Phosphate Synthase Genes in Morus notabilis
por: Zhang, Shaoyu, et al.
Publicado: (2020)

Exploring the Deoxy-D-xylulose-5-phosphate Synthase Gene Family in Tomato (Solanum lycopersicum)
por: Di, Xueni, et al.
Publicado: (2023)

Molecular Characterization of the 1-Deoxy-D-Xylulose 5-Phosphate Synthase Gene Family in Artemisia annua
por: Zhang, Fangyuan, et al.
Publicado: (2018)

Combinatorial Engineering of 1-Deoxy-D-Xylulose 5-Phosphate Pathway Using Cross-Lapping In Vitro Assembly (CLIVA) Method
por: Zou, Ruiyang, et al.
Publicado: (2013)

Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli()
por: Handa, Sumit, et al.
Publicado: (2013)

A Modified Kulka Micromethod for the Rapid and Safe Analysis of Fructose and 1-Deoxy-d-xylulose-5-phosphate
por: Shaw, Shreya, et al.
Publicado: (2018)

Characterization of a Functionally Active Recombinant 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Babesia bovis
por: WANG, Jing, et al.
Publicado: (2014)

Characterization of the 1-Deoxy-D-xylulose 5-Phosphate synthase Genes in Toona ciliata Suggests Their Role in Insect Defense
por: Wang, Yueyang, et al.
Publicado: (2023)

The Identification of β-Ocimene Biosynthetic Pathway Through Mevalonate Acid (MVA) and 1-Deoxy-D-Xylulose 5-Phosphate (DXP) Pathways Using Crude Enzyme Extracts in Indonesian Bay Leaf/Salam Leaf (Syzygium polyanthum)
por: Pratama, Bima Putra, et al.
Publicado: (2022)

Albino T-DNA tomato mutant reveals a key function of 1-deoxy-D-xylulose-5-phosphate synthase (DXS1) in plant development and survival
por: García-Alcázar, Manuel, et al.
Publicado: (2017)

Functional effect of grapevine 1-deoxy-D-xylulose 5-phosphate synthase substitution K284N on Muscat flavour formation
por: Battilana, Juri, et al.
Publicado: (2011)

Engineering of Recombinant Poplar Deoxy-D-Xylulose-5-Phosphate Synthase (PtDXS) by Site-Directed Mutagenesis Improves Its Activity
por: Banerjee, Aparajita, et al.
Publicado: (2016)

Correction: Engineering of Recombinant Poplar Deoxy-D-Xylulose-5-Phosphate Synthase (PtDXS) by Site-Directed Mutagenesis Improves Its Activity
por: Banerjee, Aparajita, et al.
Publicado: (2016)

Phage Display on the Anti‐infective Target 1‐Deoxy‐d‐xylulose‐5‐phosphate Synthase Leads to an Acceptor–Substrate Competitive Peptidic Inhibitor
por: Marcozzi, Alessio, et al.
Publicado: (2017)

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
por: Hamid, Rawia, et al.
Publicado: (2023)

Enhancing Sesquiterpenoid Production from Methane via Synergy of the Methylerythritol Phosphate Pathway and a Short-Cut Route to 1-Deoxy-D-xylulose 5-Phosphate in Methanotrophic Bacteria
por: Nguyen, Anh Duc, et al.
Publicado: (2021)

Molecular Cloning and Differential Gene Expression Analysis of 1-Deoxy-D-xylulose 5-Phosphate Synthase (DXS) in Andrographis paniculata (Burm. f) Nees
por: Srinath, Mote, et al.
Publicado: (2020)

Over-expression of a cyanobacterial gene for 1-deoxy-d-xylulose-5-phosphate synthase in the chloroplast of Chlamydomonas reinhardtii perturbs chlorophyll: carotenoid ratios
por: Hoqani, Umaima Al, et al.
Publicado: (2022)

Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase
por: Jumde, Ravindra P., et al.
Publicado: (2021)

First crystal structures of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
por: Gierse, Robin M., et al.
Publicado: (2022)

Biosynthetic studies on terpenoids produced by Streptomyces
por: Kuzuyama, Tomohisa
Publicado: (2017)

Novel Bioassay for the Discovery of Inhibitors of the 2-C-Methyl-D-erythritol 4-Phosphate (MEP) and Terpenoid Pathways Leading to Carotenoid Biosynthesis
por: Corniani, Natália, et al.
Publicado: (2014)

Altered Promoter and G-Box Binding Factor for 1-Deoxy-d-Xylulose-5-Phosphate Synthase Gene Grown from Poa pratensis Seeds after Spaceflight
por: Gan, Lu, et al.
Publicado: (2019)

Characterization and Function of the 1-Deoxy-D-xylose-5-Phosphate Synthase (DXS) Gene Related to Terpenoid Synthesis in Pinus massoniana
por: Li, Rong, et al.
Publicado: (2021)

Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway
por: Marshall, Bailey, et al.
Publicado: (2023)

Enzyme Inhibitor Studies Reveal Complex Control of Methyl-D-Erythritol 4-Phosphate (MEP) Pathway Enzyme Expression in Catharanthus roseus
por: Han, Mei, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lnu5phf0q578l3n3gif90m1t2l