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Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012

Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment...

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Autores principales: Liu, Michelle Y., Liu, Jin, Lai, Weijian, Luo, Jun, Liu, Yingle, Vu, Gia-Phong, Yang, Zhu, Trang, Phong, Li, Hongjian, Wu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150535/
https://www.ncbi.nlm.nih.gov/pubmed/27941929
http://dx.doi.org/10.1038/srep38451
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author Liu, Michelle Y.
Liu, Jin
Lai, Weijian
Luo, Jun
Liu, Yingle
Vu, Gia-Phong
Yang, Zhu
Trang, Phong
Li, Hongjian
Wu, Jianguo
author_facet Liu, Michelle Y.
Liu, Jin
Lai, Weijian
Luo, Jun
Liu, Yingle
Vu, Gia-Phong
Yang, Zhu
Trang, Phong
Li, Hongjian
Wu, Jianguo
author_sort Liu, Michelle Y.
collection PubMed
description Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3–6 years old. Laboratory studies detected a high prevalence of EV71 and suggested EV71 as the most common enterovirus causing HFMD in Shawo. Sequencing analysis showed that the EV71 strains from Shawo belong to the C4 subgenotype, and are phylogenetically more related to those from the distant city of Nanchang than those from the nearby city of Wuhan with distinct variations. More girls were found to be associated with EV71 in Shawo whereas more boys were associated with EV71 in Wuhan and Nanchang. Our studies further the understanding of the molecular epidemiological features of HFMD and infection by enteroviruses in China.
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spelling pubmed-51505352016-12-19 Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012 Liu, Michelle Y. Liu, Jin Lai, Weijian Luo, Jun Liu, Yingle Vu, Gia-Phong Yang, Zhu Trang, Phong Li, Hongjian Wu, Jianguo Sci Rep Article Infection of enterovirus 71 (EV71) and associated hand, foot, and mouth disease (HFMD) are recognized as emerging public health issues worldwide. Hundreds of thousands of children are annually infected with EV71 and develop HFMD in China alone. Studies of EV71 infection are critical to the treatment and prevention of the associated HFMD outbreaks. In this report, we studied an outbreak of 105 HFMD cases in Shawo Township of China between September to October 2012. More than 90% of cases were children younger than 9 years old, with over 50% of cases aged 3–6 years old. Laboratory studies detected a high prevalence of EV71 and suggested EV71 as the most common enterovirus causing HFMD in Shawo. Sequencing analysis showed that the EV71 strains from Shawo belong to the C4 subgenotype, and are phylogenetically more related to those from the distant city of Nanchang than those from the nearby city of Wuhan with distinct variations. More girls were found to be associated with EV71 in Shawo whereas more boys were associated with EV71 in Wuhan and Nanchang. Our studies further the understanding of the molecular epidemiological features of HFMD and infection by enteroviruses in China. Nature Publishing Group 2016-12-12 /pmc/articles/PMC5150535/ /pubmed/27941929 http://dx.doi.org/10.1038/srep38451 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Liu, Michelle Y.
Liu, Jin
Lai, Weijian
Luo, Jun
Liu, Yingle
Vu, Gia-Phong
Yang, Zhu
Trang, Phong
Li, Hongjian
Wu, Jianguo
Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
title Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
title_full Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
title_fullStr Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
title_full_unstemmed Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
title_short Characterization of enterovirus 71 infection and associated outbreak of Hand, Foot, and Mouth Disease in Shawo of China in 2012
title_sort characterization of enterovirus 71 infection and associated outbreak of hand, foot, and mouth disease in shawo of china in 2012
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150535/
https://www.ncbi.nlm.nih.gov/pubmed/27941929
http://dx.doi.org/10.1038/srep38451
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