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WRN regulates pathway choice between classical and alternative non-homologous end joining

Werner syndrome (WS) is an accelerated ageing disorder with genomic instability caused by WRN protein deficiency. Many features seen in WS can be explained by the diverse functions of WRN in DNA metabolism. However, the origin of the large genomic deletions and telomere fusions are not yet understoo...

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Detalles Bibliográficos
Autores principales:	Shamanna, Raghavendra A., Lu, Huiming, de Freitas, Jessica K., Tian, Jane, Croteau, Deborah L., Bohr, Vilhelm A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150655/ https://www.ncbi.nlm.nih.gov/pubmed/27922005 http://dx.doi.org/10.1038/ncomms13785

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