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Measurement of Ligand–Target Residence Times by (1)H Relaxation Dispersion NMR Spectroscopy

[Image: see text] A ligand-observed (1)H NMR relaxation experiment is introduced for measuring the binding kinetics of low-molecular-weight compounds to their biomolecular targets. We show that this approach, which does not require any isotope labeling, is applicable to ligand–target systems involvi...

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Detalles Bibliográficos
Autores principales:	Moschen, Thomas, Grutsch, Sarina, Juen, Michael A., Wunderlich, Christoph H., Kreutz, Christoph, Tollinger, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150660/ https://www.ncbi.nlm.nih.gov/pubmed/27933946 http://dx.doi.org/10.1021/acs.jmedchem.6b01110

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